STROKE ACUTE

This Phase 3 trial tests whether the drug tirofiban can help people who have had a stroke but missed the usual treatment window (more than 24 hours after symptoms start). The study uses a special MRI scan to select patients whose stroke is caused by a specific type of artery bloc…

This study looks at whether removing a large blood clot from the brain (endovascular thrombectomy) is better than standard medical care for stroke patients who already had a moderate-to-severe disability before their stroke. About 1,060 adults with a recent stroke and a pre-exist…

This study tests whether a newer clot-dissolving drug (tenecteplase) works better than the standard drug (alteplase) when given before a mechanical procedure to remove a large blood clot from the brain. About 850 adults who have had a severe stroke within the last 4.5 hours will …

This study tests whether taking stroke patients straight to the angiography suite for clot removal, instead of first evaluating them in the emergency department, leads to better recovery. About 2,000 adults with severe stroke symptoms within 7 hours will be randomly assigned to o…

This study tests whether taking stroke patients directly to a special imaging and treatment room (angio suite) speeds up care compared to the usual approach of getting a CT or MRI first. About 594 adults with severe stroke symptoms will be randomly assigned to one of the two path…

This trial tests whether doing brain scans and clot-removal procedures in the same room speeds up treatment for severe strokes. About 390 patients with suspected large-vessel blockages will be randomly assigned to either the usual two-room process or a one-room approach. The goal…

This study tests a weight-loss program delivered via telehealth for people who have had a stroke. The goal is to help participants lose weight and improve their health, especially those in underserved communities. The study will compare the program to a wait-list control group an…

This global study tests whether a procedure that removes blood clots from the brain can safely help stroke patients treated up to 72 hours after symptoms start, using only a basic CT scan that is available in most hospitals. Currently, this treatment is only proven within 6 hours…

This study looks at whether adding a non-invasive brain stimulation technique (rTMS) to standard swallowing therapy can reduce pneumonia in stroke patients who have trouble swallowing. About 70 adults aged 49-65 with moderate to severe swallowing problems after a stroke will be e…

This phase 3 trial is testing two different doses of the clot-busting drug tenecteplase in 4,000 people who have had an acute ischemic stroke. The goal is to find out which dose works best and is safest, especially for patients who have taken blood thinners or are undergoing a pr…

This trial tests a wearable bracelet called Stroke Alarm that detects when a stroke causes arm weakness. People aged 50 and older with certain high-risk conditions (like recent mini-stroke, atrial fibrillation, or artery disease) wear the device for 3 months. The goal is to see i…

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This study tests whether a gentle, non-invasive nerve stimulation (called tVNS) applied to the ear or neck can improve arm movement, thinking, and quality of life when paired with standard therapy in people who had a stroke 3–6 months ago. About 54 adults who had their first isch…

This study tests a wearable device called a myoelectric-computer interface (MCI) that helps stroke survivors improve arm movement by reducing abnormal muscle co-activation. The device uses muscle signals to guide a video game, providing feedback to retrain coordination. Researche…

This pilot study tests whether a low-cost virtual reality (VR) system can help people recovering from a first-time stroke improve their arm movement. Researchers will compare VR therapy to standard care in 40 adults with moderate to severe arm weakness. Participants will use a Me…

This study tests whether adding immersive virtual reality (VR) to standard physical therapy helps people who recently had a stroke regain arm movement and improve quality of life. Researchers will also look at blood markers and genes that might predict recovery. About 120 adults …

This study tests a new set of procedures called the HI-SPEED Protocol, designed to help hospitals evaluate stroke patients faster and decide who needs to be transferred for advanced care. The goal is to reduce the time patients spend in the first hospital before being moved to a …

This study looks at how artificial intelligence (AI) can help emergency call operators quickly identify life-threatening situations like cardiac arrest, stroke, or severe breathing problems. Researchers will analyze millions of past emergency calls to train AI models to recognize…

This study examines blood samples from 300 adults who had a stroke and received a procedure to remove the clot. Researchers look for specific RNA molecules that change before and after treatment. The goal is to find markers that can help predict how well patients will recover and…

This study tracks 350 stroke patients across the Asia-Pacific to see how well a proven clot-removal procedure (endovascular thrombectomy) works in everyday hospitals, not just in controlled trials. Researchers will analyze patient outcomes, imaging, and even the removed clots to …

This study tests whether a 3D image overlay (fusion imaging) helps doctors reach and remove blood clots in the brain faster during a standard stroke procedure. About 300 adults having emergency clot removal will be randomly assigned to get the extra imaging or not. The goal is to…

This study aims to understand if COVID-19 vaccines have any impact on brain health in healthy people. Researchers will use MRI scans to look for changes in the brain's blood vessels and structure. The study will follow 500 adults from Hong Kong who have already had a baseline bra…

This long-term study is tracking 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk due to family history or early signs. Researchers will collect medical records and questionnaires every 6 months to find what factors lead to b…

This study is testing a new type of MRI scanner, called Field-Cycling Imaging (FCI), to see if it can detect brain changes within the first day of a stroke. Researchers will compare FCI scans with standard MRI scans in 40 acute stroke patients. Participants will also provide bloo…

This study looks at blood clots removed from stroke patients during a procedure called thrombectomy. Researchers will also take a small blood sample. They want to see if the clot's makeup and blood markers can tell us more about what caused the stroke, how well treatment worked, …

This study is collecting data from 5,000 people who had a stroke caused by a blood clot and received endovascular treatment (a procedure to remove the clot). The goal is to measure how well patients recover neurologically three months later. This information is rarely collected b…

This study looks at whether a nurse-led transitional care program helps stroke survivors and their caregivers after leaving the hospital. About 130 stroke survivors, their caregivers, and healthcare workers in Tanzania will take part. The program includes face-to-face sessions an…

This study tests whether a simple CT scan (NCCT) works as well as advanced imaging (CTP/MRI) for choosing stroke patients who need emergency clot removal. About 1,846 adults with acute stroke arriving within 24 hours of symptoms will be enrolled. The goal is to see if the simpler…

This study aims to see if brain scans and a technique called transcranial magnetic stimulation (TMS) can predict how well someone will recover arm movement after a stroke. Researchers will collect data from 657 adults who recently had a stroke and have arm weakness. The goal is t…

This observational study tests a new physical exam method to reliably find joint motion problems in healthy adults and people hospitalized with stroke or TIA. Researchers will compare motion patterns between groups and see if motion issues relate to quality of life after stroke. …

This study will measure a protein called BD-tau in the blood of 100 people who have had an acute ischemic stroke. Researchers will take blood samples every hour for 48 hours to see how the protein levels change over time. The goal is to better understand brain injury patterns and…