Stroke drug dosing trial aims to improve recovery for thousands
NCT ID NCT06320431
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This phase 3 trial is testing two different doses of the clot-busting drug tenecteplase in 4,000 people who have had an acute ischemic stroke. The goal is to find out which dose works best and is safest, especially for patients who have taken blood thinners or are undergoing a procedure to remove the clot. Researchers will track patients for 90 days to see how well they recover and whether they have any side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
tenecteplase (a clot-busting drug)
What this could lead to
If successful, this trial could identify the safest and most effective dose of tenecteplase for different stroke patients, potentially improving recovery and reducing disability.
What could go wrong
This is an early-phase study with 4,000 participants, and results may not apply to all stroke patients. There is a risk of bleeding, a known side effect of clot-busting drugs.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Brandon Regional Hospital
NOT_YET_RECRUITINGBrandon, Manitoba, Canada
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CIUSSS de l'Estrie - CHUS Fleurimont Hôpital (Sherbrooke)
NOT_YET_RECRUITINGSherbrooke, Quebec, Canada
Contact Email: •••••@•••••
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Centre Hospitalier de l'Université de Montréal (CHUM)
NOT_YET_RECRUITINGMontreal, Quebec, Canada
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Health Sciences North Horizon Sante-Nord
RECRUITINGGreater Sudbury, Ontario, Canada
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Kelowna Regional Hospital
NOT_YET_RECRUITINGKelowna, British Columbia, Canada
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Kingston General Hospital
NOT_YET_RECRUITINGKingston, Ontario, Canada
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Lawson Health Research Institute- London
NOT_YET_RECRUITINGLondon, Ontario, Canada
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McMaster University Hamilton Health Sciences Centre
RECRUITINGHamilton, Ontario, Canada
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Medicine Hat Regional Hospital
NOT_YET_RECRUITINGMedicine Hat, Alberta, Canada
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Monash University (Box Hill)
RECRUITINGMelbourne, Victoria, Australia
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Queen Elizabeth Hospital (PEI)
RECRUITINGCharlottetown, Prince Edward Island, Canada
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Queen Elizabeth II Health Science Center (Halifax)
NOT_YET_RECRUITINGHalifax, Nova Scotia, Canada
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Red Deer Regional Hospital
NOT_YET_RECRUITINGRed Deer, Alberta, Canada
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Royal Columbian Hospital
NOT_YET_RECRUITINGNew Westminster, British Columbia, Canada
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Royal Prince Alfred Hospital
RECRUITINGSydney, New South Wales, Australia
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Royal University Hospital
RECRUITINGSaskatoon, Saskatchewan, Canada
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St. Michael's Hospital
RECRUITINGToronto, Ontario, Canada
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Sunnybrook Health Science Centre
RECRUITINGToronto, Ontario, Canada
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The George Institute for Global Health
NOT_YET_RECRUITINGSydney, Barangaroo, NSW 2000, Australia
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University of Alberta
RECRUITINGEdmonton, A, Canada
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University of British Columbia
RECRUITINGVancouver, British Columbia, Canada
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University of Calgary
RECRUITINGCalgary, Alberta, T2N 1N4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Manitoba - Winnipeg Health Science Centre
RECRUITINGWinnipeg, Manitoba, Canada
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University of Ottawa
RECRUITINGOttawa, Ontario, Canada
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