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Sound waves open brain barrier to attack deadly tumor

NCT ID NCT06329570

Recruiting now Disease control Sponsor: NaviFUS Corporation Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study tests a combination approach for recurrent glioblastoma, an aggressive brain cancer. The treatment uses focused ultrasound (NaviFUS) to temporarily open the blood-brain barrier, allowing the drug Avastin (bevacizumab) to reach the tumor more effectively. Ten adults whose cancer has returned after standard therapy will be enrolled to see if this method is safe and helps control tumor growth for at least six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Bevacizumab (Avastin) combined with focused ultrasound (NaviFUS system) and microbubbles
What this could lead to
If it works, this could point toward a way to deliver drugs more effectively to brain tumors, potentially improving control of recurrent glioblastoma.
What could go wrong
This is a very early, small pilot study with only 10 people. It is designed mainly to check safety, not to prove the treatment works. The combination may not improve outcomes and could have side effects from the ultrasound or drug.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm glioblastoma glioma glioma susceptibility 1 neoplasm Neoplasms, Nerve Tissue nervous system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN TUMOR GLIOBLASTOMA GLIOBLASTOMA MULTIFORME GLIOMA NEOPLASMS NEOPLASMS, NERVE TISSUE

Contacts and locations

Locations

  • University of Virginia

    RECRUITING

    Charlottesville, Virginia, 22903, United States

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