New combo treatment aims to tackle deadly brain tumors

NCT ID NCT04699773

Recruiting now Disease control Sponsor: University of Maryland, Baltimore Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a two-step treatment for people with newly diagnosed high-grade gliomas, a type of aggressive brain cancer. First, doctors use a laser to heat and destroy tumor tissue, then follow up with a shorter course of radiation. The goal is to see if this approach is safe and helps control the tumor. About 32 adults will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Laser interstitial thermal therapy (LITT) and hypofractionated radiation therapy
What this could lead to: If successful, this combination could offer a new, safer treatment option for people with aggressive brain tumors, potentially improving survival without severe side effects.
What could go wrong: This is an early-phase study with only 32 participants, so results may not apply to everyone. There is a risk of serious side effects like bleeding or neurological damage.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm glioblastoma glioma malignant glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN TUMOR GLIOBLASTOMA GLIOMA

Contacts and locations

Locations

Baltimore Washington Medical Center
RECRUITING

Glen Burnie, Maryland, 21061, United States
Central Maryland Radiation Oncology
RECRUITING

Columbia, Maryland, 21044, United States
Maryland Proton Treatment Center
RECRUITING

Baltimore, Maryland, 21201, United States
UCH Kaufman Cancer Center
RECRUITING

Bel Air, Maryland, 21014, United States
University of Maryland Greenebaum Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States

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