Brain-Sparing radiation may shield young minds from treatment side effects
NCT ID NCT05658731
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This study explores whether planning radiation therapy to avoid key brain regions can reduce thinking and learning problems in children with brain or head and neck tumors. Participants include children receiving radiation, survivors who completed radiation at least two years ago, and healthy children for comparison. Researchers will use MRI scans and cognitive tests to measure brain changes and mental performance over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
radiation therapy with substructure-informed planning
What this could lead to
If successful, this approach could help preserve thinking and learning abilities in children who need radiation for brain or head and neck tumors.
What could go wrong
This is an early-stage feasibility study, so it may not prove that the planning method actually protects cognitive function. The results may not apply to all tumor types or radiation techniques.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Johns Hopkins Hospital
RECRUITINGBaltimore, Maryland, 21287, United States
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Sibley Memorial Hospital
RECRUITINGWashington D.C., District of Columbia, 20016, United States