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Lung germ shifts may predict pneumonia in brain surgery ICU patients

NCT ID NCT07129174

Recruiting now Knowledge-focused Sponsor: Jian-Xin Zhou Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

After brain surgery, many patients need a breathing machine in the ICU. This study will follow 220 such patients to see how the natural bacteria in their lungs change over time. Researchers will collect airway samples and use advanced lab tests to link those changes to the risk of developing pneumonia. The goal is to find early warning signs of lung infection and improve care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could help doctors predict lung infections earlier in ICU patients after brain surgery, leading to more personalized antibiotic use.
What could go wrong
This is an observational study, not a treatment trial. It will not test any new drug or therapy, so direct patient benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain neoplasm Pneumonia, Ventilator-Associated subarachnoid hemorrhage traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTENSIVE CARE UNIT (ICU) PATIENTS MICROBIOME DYSBIOSIS VENTILATOR-ASSOCIATED PNEUMONIA (VAP)

Contacts and locations

Locations

  • Beijing Anzhen Hospital, Capital Medical University

    RECRUITING

    Beijing, Beijing Municipality, 101100, China

  • Beijing Shijitan Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100038, China

  • Beijing Tiantan Hospital, Capital Medical University

    RECRUITING

    Beijing, Beijing Municipality, 100050, China

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