VENTILATOR-ASSOCIATED PNEUMONIA (VAP)

This study compares two approaches for treating suspected ventilator-associated pneumonia (VAP) in ICU patients who are not severely ill. One group gets antibiotics immediately, while the other waits for lab confirmation. The goal is to see if waiting reduces unnecessary antibiot…

Some bacterial infections have become resistant to common antibiotics, making them very hard to treat. This study looks at a new drug combination, aztreonam-avibactam, in about 100 hospitalized adults in China with these resistant infections. Researchers will track how well patie…

This study tests whether inhaling an antibiotic called colistin can prevent ventilator-associated pneumonia (VAP) in ICU patients at high risk for drug-resistant infections. About 508 adults on breathing machines for at least two days will receive either colistin or a placebo via…

After brain surgery, many patients need a breathing machine in the ICU. This study will follow 220 such patients to see how the natural bacteria in their lungs change over time. Researchers will collect airway samples and use advanced lab tests to link those changes to the risk o…

This study watches 170 ICU patients on breathing machines to see if a temporary immune system weakness (called immunoparalysis) raises the chance of getting pneumonia. Researchers will measure immune markers in elderly patients (65+), younger adults, and healthy volunteers. The g…

This study tests whether monitoring changes in airway resistance can help doctors decide the best time to suction mucus from the lungs of patients on ventilators. Researchers will use machine learning to analyze data from 258 patients with conditions like ARDS or severe pneumonia…

This study tests whether training intensive care nurses in evidence-based practices and providing new equipment (like closed suction catheters and mouth care brushes) can lower the rate of ventilator-associated pneumonia (VAP) in a Bangladesh hospital. Researchers will compare in…