New study questions rush to antibiotics for ventilator lung infections

NCT ID NCT06743529

Recruiting now Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two approaches for treating suspected ventilator-associated pneumonia (VAP) in ICU patients who are not severely ill. One group gets antibiotics immediately, while the other waits for lab confirmation. The goal is to see if waiting reduces unnecessary antibiotic use without increasing deaths or time on a ventilator. About 686 adults on ventilators for more than 48 hours will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: antibiotics
What this could lead to: If it works, this could show that waiting for lab confirmation before starting antibiotics is safe for non-severe VAP, reducing unnecessary antibiotic use and fighting resistance.
What could go wrong: This is an early-stage trial with 686 participants. The conservative strategy might delay treatment for some infected patients, potentially worsening outcomes. Results may not apply to severe cases.

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Conditions

The condition(s) this trial relates to.

Pneumonia, Ventilator-Associated

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VENTILATOR-ASSOCIATED PNEUMONIA (VAP)

Contacts and locations

Locations

APHP - Hôpital Cochin
RECRUITING

Paris, 75014, France
APHP - Hôpital Raymond Poincaré
RECRUITING

Garches, 92380, France
APHP - Hôpital Tenon
RECRUITING

Paris, 75020, France
CH Angoulème
RECRUITING

Angoulème, France, 16000, France
CH Argenteuil
RECRUITING

Argenteuil, France, 95100, France
CH Avignon
RECRUITING

Avignon, 84000, France
CH Bretagne Atlantique
RECRUITING

Vannes, 56017, France
CH Cholet
RECRUITING

Cholet, 49325, France
CH Dax
RECRUITING

Dax, 40107, France
CH Emile Roux
RECRUITING

Le Puy-en-Velay, 43000, France
CH Le Mans
RECRUITING

Le Mans, 72000, France
CH Public du Cotentin
RECRUITING

Cherbourg, 50102, France
CH Simone Veil
RECRUITING

Cannes, 06414, France
CH Versailles
RECRUITING

Le Chesnay, 78157, France
CH d'Arles
RECRUITING

Arles, 13637, France
CH de Melun
RECRUITING

Melun, 77000, France
CH de Mont de Marsan
RECRUITING

Mont-de-Marsan, 40000, France
CH de Pau
RECRUITING

Pau, 64000, France
CH de Saint-Malo
RECRUITING

St-Malo, 35403, France
CH de Saint-Nazaire
RECRUITING

Saint-Nazaire, 44600, France
CH de Valenciennes
RECRUITING

Valenciennes, 59300, France
CHD Vendée
RECRUITING

La Roche-sur-Yon, 85025, France
CHR d'Orléans
RECRUITING

Orléans, 45100, France
CHRU De Tours
RECRUITING

Tours, 37044, France
CHRU Lille
RECRUITING

Lille, 59037, France
CHRU de Strasbourg - Nouvel Hôpital Civil
RECRUITING

Strasbourg, 67091, France
CHRU de Strasbourg -Hôpital de Hautepierre
RECRUITING

Strasbourg, 67098, France
CHU Angers
RECRUITING

Angers, France, 49000, France
CHU Clermont-Ferrand
RECRUITING

Clermont-Ferrand, 63003, France
CHU Dijon
RECRUITING

Dijon, 21033, France
CHU La Guadeloupe
RECRUITING

Pointe-à-Pitre, 97159, Guadeloupe
CHU Nantes
RECRUITING

Nantes, France, 44000, France
CHU Nice - Hôpital de l'Archet
RECRUITING

Nice, 06200, France
CHU Nice -Hôpital Pasteur
RECRUITING

Nice, 06100, France
CHU Rennes
RECRUITING

Rennes, 35033, France
CHU de Bordeaux
RECRUITING

Bordeaux, 33076, France
CHU de Bordeaux
RECRUITING

Bordeaux, France
CHU de Lyon - Hôpital Edouard Herriot
RECRUITING

Lyon, 69437, France
GHB Sud- Hôpital de Lorient
RECRUITING

Lorient, 56100, France
Hôpital Foch
RECRUITING

Suresnes, 92150, France
Hôpital Nord Franche Comté
RECRUITING

Belfort, 90000, France

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