New study questions rush to antibiotics for ventilator lung infections
NCT ID NCT06743529
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two approaches for treating suspected ventilator-associated pneumonia (VAP) in ICU patients who are not severely ill. One group gets antibiotics immediately, while the other waits for lab confirmation. The goal is to see if waiting reduces unnecessary antibiotic use without increasing deaths or time on a ventilator. About 686 adults on ventilators for more than 48 hours will take part.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
antibiotics
What this could lead to
If it works, this could show that waiting for lab confirmation before starting antibiotics is safe for non-severe VAP, reducing unnecessary antibiotic use and fighting resistance.
What could go wrong
This is an early-stage trial with 686 participants. The conservative strategy might delay treatment for some infected patients, potentially worsening outcomes. Results may not apply to severe cases.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for VENTILATOR-ASSOCIATED PNEUMONIA (VAP) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
APHP - Hôpital Cochin
RECRUITINGParis, 75014, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
APHP - Hôpital Raymond Poincaré
RECRUITINGGarches, 92380, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
APHP - Hôpital Tenon
RECRUITINGParis, 75020, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH Angoulème
RECRUITINGAngoulème, France, 16000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH Argenteuil
RECRUITINGArgenteuil, France, 95100, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH Avignon
RECRUITINGAvignon, 84000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH Bretagne Atlantique
RECRUITINGVannes, 56017, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH Cholet
RECRUITINGCholet, 49325, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH Dax
RECRUITINGDax, 40107, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH Emile Roux
RECRUITINGLe Puy-en-Velay, 43000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH Le Mans
RECRUITINGLe Mans, 72000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH Public du Cotentin
RECRUITINGCherbourg, 50102, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH Simone Veil
RECRUITINGCannes, 06414, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH Versailles
RECRUITINGLe Chesnay, 78157, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH d'Arles
RECRUITINGArles, 13637, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH de Melun
RECRUITINGMelun, 77000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH de Mont de Marsan
RECRUITINGMont-de-Marsan, 40000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH de Pau
RECRUITINGPau, 64000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH de Saint-Malo
RECRUITINGSt-Malo, 35403, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH de Saint-Nazaire
RECRUITINGSaint-Nazaire, 44600, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CH de Valenciennes
RECRUITINGValenciennes, 59300, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHD Vendée
RECRUITINGLa Roche-sur-Yon, 85025, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHR d'Orléans
RECRUITINGOrléans, 45100, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHRU De Tours
RECRUITINGTours, 37044, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHRU Lille
RECRUITINGLille, 59037, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHRU de Strasbourg - Nouvel Hôpital Civil
RECRUITINGStrasbourg, 67091, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHRU de Strasbourg -Hôpital de Hautepierre
RECRUITINGStrasbourg, 67098, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHU Angers
RECRUITINGAngers, France, 49000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHU Clermont-Ferrand
RECRUITINGClermont-Ferrand, 63003, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHU Dijon
RECRUITINGDijon, 21033, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHU La Guadeloupe
RECRUITINGPointe-à-Pitre, 97159, Guadeloupe
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHU Nantes
RECRUITINGNantes, France, 44000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHU Nice - Hôpital de l'Archet
RECRUITINGNice, 06200, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHU Nice -Hôpital Pasteur
RECRUITINGNice, 06100, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHU Rennes
RECRUITINGRennes, 35033, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHU de Bordeaux
RECRUITINGBordeaux, 33076, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHU de Bordeaux
RECRUITINGBordeaux, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
CHU de Lyon - Hôpital Edouard Herriot
RECRUITINGLyon, 69437, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
GHB Sud- Hôpital de Lorient
RECRUITINGLorient, 56100, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hôpital Foch
RECRUITINGSuresnes, 92150, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hôpital Nord Franche Comté
RECRUITINGBelfort, 90000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••