Sound waves may unlock Brain's barrier to fight tumors

NCT ID NCT05733312

Recruiting now Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses focused ultrasound to temporarily open the blood-brain barrier during brain tumor surgery. Researchers will place tiny catheters to sample fluid from different brain areas to see how the barrier affects the tumor environment. Only 6 adults with large brain tumors will take part, and the goal is to gather information, not to treat the tumor.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: focused ultrasound (ExAblate Neuro device)
What this could lead to: If successful, this could reveal how the blood-brain barrier affects drug delivery to brain tumors, potentially guiding future treatments.
What could go wrong: This is a very small, early-stage study (6 people) focused on measurement, not treatment. It may not lead to direct benefits for participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer brain neoplasm glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRAIN TUMOR

Contacts and locations

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Locations

Mayo Clinic Minnesota
RECRUITING

Rochester, Minnesota, 55905, United States

Contact Email: •••••@•••••

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