Brain tumor DNA test could match kids to smarter treatments
NCT ID NCT05839379
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study uses genetic testing of brain tumors from children, adolescents, and young adults (ages 1 to 39) with newly diagnosed high-grade glioma, including DIPG. The goal is to identify specific genetic changes in each tumor and then see if patients can join a treatment trial tailored to those changes. Up to 350 participants will have their tumors analyzed, and researchers will also study inherited cancer risks. This is a screening study, not a direct treatment trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors choose more effective, personalized treatments for young brain tumor patients based on their tumor's genetic makeup.
- What could go wrong
- This is an early-stage screening study, not a treatment trial. It may not lead to better outcomes for all participants, and some patients may not be eligible for a targeted therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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C.S. Mott Children's Hospital
RECRUITINGAnn Arbor, Michigan, 48109, United States
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Children's Hospital Colorado
NOT_YET_RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's National Medical Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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Dana-Farber Cancer Institute
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
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Duke University Health System
RECRUITINGDurham, North Carolina, 27708, United States
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Great Ormond Street Hospital
NOT_YET_RECRUITINGLondon, WC1N 3JH, United Kingdom
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Hopp Children's Cancer Center at NCT Heidelberg (KiTZ)
NOT_YET_RECRUITINGHeidelberg, Baden-Wurttemberg, 69120, Germany
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Montreal Children's Hospital
NOT_YET_RECRUITINGMontreal, Quebec, H4A3J1, Canada
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43205, United States
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Perth Children's Hospital
RECRUITINGPerth, Western Australia, 6000, Australia
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Princess Máxima Center
NOT_YET_RECRUITINGUtrecht, 3720, Netherlands
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Queensland Children's Hospital
RECRUITINGSouth Brisbane, Queensland, 4101, Australia
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Royal Children's Hospital
RECRUITINGMelbourne, Victoria, 3052, Australia
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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Starship Children's Hospital
NOT_YET_RECRUITINGAuckland, Grafton, 1023, New Zealand
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Sydney Children's Hospital
RECRUITINGRandwick, New South Wales, 2031, Australia
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Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
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The Hospital for Sick Children (SickKids)
NOT_YET_RECRUITINGToronto, Ontario, M5G1X8, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can trained immune cells outsmart brain tumors?
- New imaging clues could sharpen brain tumor monitoring
- Can a virus injected into brain tumors fight recurrence?
- Could cutting a wider margin around brain tumors extend survival?
- Can a Tumor's genetic blueprint guide better treatment for kids with brain cancer?
- Can engineered immune cells tackle an incurable childhood brain tumor?