Gene-Edited stem cells may let doctors use stronger chemo against brain cancer

This study tests a new approach for people with a recently removed glioblastoma (a fast-growing brain tumor). Doctors take some of the patient's own blood stem cells, add a protective gene (P140K MGMT) to them, and return them to the patient. This allows the use of higher doses of chemotherapy drugs (temozolomide and O6-benzylguanine) to kill more tumor cells while protecting the bone marrow from damage. The trial aims to see if this treatment is safe and helps patients live longer.