Sound waves open brain barrier to attack deadly tumor

NCT ID NCT05864534

Recruiting now Disease control Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This trial tests a new approach for glioblastoma, an aggressive brain cancer. A device implanted in the skull uses ultrasound to temporarily open the blood-brain barrier, allowing immune-boosting drugs to reach the tumor. The study involves 25 adults who have completed radiation, and aims to see if the combination is safe and extends survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Balstilimab, Botensilimab, Liposomal Doxorubicin
What this could lead to: If successful, this could offer a new way to treat glioblastoma by helping drugs reach the brain more effectively, potentially improving survival.
What could go wrong: This is an early phase 2a trial with only 25 people, so results may not apply widely. The treatment involves brain surgery to implant a device, and immune drugs can cause serious side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma glioma susceptibility 1 gliosarcoma IDH-wildtype glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA MULTIFORME GLIOBLASTOMA, ISOCITRIC DEHYDROGENASE (IDH)-WILDTYPE GLIOSARCOMA NEWLY DIAGNOSED GLIOBLASTOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••

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