New device targets recurrent brain tumors in early trial

NCT ID NCT05303467

Recruiting now Disease control Sponsor: Boston Scientific Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This early study tests a device called TheraSphere GBM in 36 people whose glioblastoma has come back after prior treatment. The device delivers tiny radioactive beads directly to the tumor to try to control it. The main goal is to check if the procedure is safe, not yet whether it works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TheraSphere GBM (Y-90 glass microspheres delivered via device)
What this could lead to: If successful, this could point toward a new treatment option for recurrent glioblastoma, potentially slowing tumor growth.
What could go wrong: This is a very early Phase 1 safety study with only 36 participants. It is not designed to prove effectiveness, and there are risks of serious side effects like brain radiation necrosis or blood-related toxicities.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma glioma susceptibility 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA MULTIFORME RECURRENT GLIOBLASTOMA

Contacts and locations

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Locations

Johns Hopkins Interventional Radiology Center
WITHDRAWN

Baltimore, Maryland, 21287, United States
Lenox Hill Hospital
RECRUITING

New York, New York, 10075, United States
MD Anderson Cancer Center
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Mayo Jacksonville
RECRUITING

Jacksonville, Florida, 32224, United States
Northwestern Univerity
RECRUITING

Chicago, Illinois, 60611, United States
University of Alabama Birmingham
WITHDRAWN

Birmingham, Alabama, 35294, United States
University of California San Diego
NOT_YET_RECRUITING

San Diego, California, 92103, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States

Contact Email: •••••@•••••
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63130, United States

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