Brain cancer gene therapy trial aims to boost survival
NCT ID NCT03603405
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a gene therapy called HSV-tk, given with valacyclovir, alongside standard radiation and chemotherapy for newly diagnosed glioblastoma or anaplastic astrocytoma. The goal is to see if this combination improves overall survival. About 62 participants will be followed for up to 5 years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
gene therapy (HSV-tk) plus valacyclovir
What this could lead to
If successful, this could offer a new way to extend survival for people with aggressive brain cancers like glioblastoma.
What could go wrong
This is an early-phase trial with only 62 participants, so results may not apply widely. Gene therapy carries risks like inflammation or infection at the injection site.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Houston Methodist Neurological Institute
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••