The Methodist Hospital Research Institute

This study is testing if a device called a bone stimulator can help athletes with a specific back injury (spondylolysis) heal better. Researchers want to see if using the device along with physical therapy helps reduce pain, improve healing of the bone, and allows athletes to ret…

This study is testing whether adding a drug called fruquintinib to standard chemotherapy works better as a first treatment for advanced colorectal cancer that cannot be removed by surgery. Fifty patients will receive the combination treatment in monthly cycles, with the goal of c…

This study is testing a new treatment approach for men with high-risk prostate cancer that hasn't spread. It adds a powerful, targeted dose of radiation directly to the prostate a few weeks before the standard robotic surgery to remove it. The goal is to see if this combined appr…

This study is testing whether a surgically implanted device that delivers mild electrical stimulation to the neck spinal cord can help people with spinal cord injuries regain control of their arms and hands. Twelve participants will have the device implanted and undergo intensive…

This study is testing a special pre-surgery program designed to help frail patients get stronger before major cancer surgery. The program includes nutrition advice, breathing exercises, and physical training. Researchers want to see if this preparation helps patients have fewer c…

This study is testing if adding an antiviral drug (valganciclovir) to standard care can help control breast cancer that has spread to the brain in patients who also have a common virus called CMV. It will enroll about 28 adults to see if the treatment shrinks tumors, improves sur…

This study is testing a new three-drug combination for people with a rare and aggressive type of breast cancer called metaplastic breast cancer (MpBC), which has stopped responding to standard treatments. The goal is to see if adding two new drugs (alpelisib and L-NMMA) to a stan…

This study is testing whether personalized brain stimulation can help people recover arm movement after a stroke. Researchers will use a gentle electrical current on the scalp during occupational therapy sessions. The study includes 80 people who had a stroke more than 3 months a…

This early-stage study is testing whether stem cells taken from a patient's own knee fat during ACL surgery can be safely injected back to help the knee heal better. Fifteen adults having ACL reconstruction will receive one injection of their processed cells and be monitored for …

This study is testing if a gentle, non-invasive stimulation of a nerve in the ear, given during hand therapy, can help improve arm and hand movement for people who have had a stroke. Researchers will enroll 60 adults who are at least 6 months past their stroke and have lasting ar…

This study is for people with a specific type of advanced breast cancer that has continued to grow despite standard hormone therapy. Researchers want to see if starting one drug a month before adding a second drug is more effective than starting both together. The goal is to find…

This study is testing whether a non-invasive brain stimulation technique can reduce overactive bladder symptoms in women with multiple sclerosis (MS). Participants will receive either real or sham stimulation sessions targeting specific brain areas. The goal is to see if this app…

This study is testing whether a one-month program of guided arm exercises delivered via video calls at home is practical and helpful for people who had a stroke more than six months ago, some of whom also have vascular dementia. The main goal is to see if this remote therapy can …

This large study is testing whether adding spiritual care from a chaplain or psychotherapy/meditation sessions to standard medical care helps people with advanced, incurable cancer live longer. It will also measure if these supportive services improve patients' quality of life an…

This small pilot study is testing whether playing voice recordings from loved ones can help manage delirium (sudden, severe confusion) in intensive care unit (ICU) patients. Fifteen surgical ICU patients at risk for delirium will listen to 20-25 minute recordings twice daily for …

This study is testing whether a CBD medication called Epidiolex can help reduce pain when used alongside standard painkillers after shoulder surgery. Researchers will compare the CBD to a placebo (inactive solution) in 80 patients. Participants will track their daily pain and med…

This study aims to use MRI scans to identify which artery blockages in the legs are most difficult to treat with standard procedures. Researchers will scan patients before their artery-opening procedures and test different medical devices on donated limbs to see which cause less …