Olive extract joins chemo in fight against advanced colon cancer
NCT ID NCT06833866
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-phase trial tests whether adding hydroxytyrosol, a natural compound found in olives, to standard chemotherapy can safely help people with advanced or metastatic colorectal cancer. About 33 adults who are eligible for first-line treatment will take a daily capsule of hydroxytyrosol for two weeks before and during their chemo cycles. The main goal is to check safety and how the body processes the combination, while also tracking tumor response and progression-free survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Hydroxytyrosol (a natural compound from olives) combined with standard chemotherapy (FOLFIRI/FOLFOX) and biologics
- What this could lead to
- If it works, this could point toward a way to make standard chemotherapy more effective for advanced colorectal cancer.
- What could go wrong
- This is a very early Phase 1 trial with only 33 people, focused on safety. It may not show any benefit, and the combination could cause additional side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Houston Methodist.
RECRUITINGHouston, Texas, 77030, United States