Olive extract joins chemo in fight against advanced colon cancer
NCT ID NCT06833866
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This early-phase trial tests whether adding hydroxytyrosol, a natural compound found in olives, to standard chemotherapy can safely help people with advanced or metastatic colorectal cancer. About 33 adults who are eligible for first-line treatment will take a daily capsule of hydroxytyrosol for two weeks before and during their chemo cycles. The main goal is to check safety and how the body processes the combination, while also tracking tumor response and progression-free survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hydroxytyrosol (a natural compound from olives) combined with standard chemotherapy (FOLFIRI/FOLFOX) and biologics
What this could lead to
If it works, this could point toward a way to make standard chemotherapy more effective for advanced colorectal cancer.
What could go wrong
This is a very early Phase 1 trial with only 33 people, focused on safety. It may not show any benefit, and the combination could cause additional side effects.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Houston Methodist.
RECRUITINGHouston, Texas, 77030, United States
Contact Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact