Could CBD be the next painkiller for shoulder surgery patients?

NCT ID NCT06381791

Recruiting now Symptom relief Sponsor: The Methodist Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether Epidiolex (a CBD medicine) can help control pain after shoulder surgery when added to standard painkillers. About 80 adults having rotator cuff repair will take either CBD or a placebo for two weeks after surgery. They will track their pain and medication use daily, and researchers will check for side effects and changes in pain-related disability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cannabidiol (Epidiolex)
What this could lead to: If it works, this could point toward a safe, non-opioid option for managing pain after orthopedic surgery.
What could go wrong: This is an early-phase trial with only 80 people, so results may not apply to everyone. CBD can cause side effects like drowsiness or liver issues, and it may not reduce pain better than a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ROTATOR CUFF INJURIES are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

osteoarthritis Rotator Cuff Injuries rotator cuff syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ROTATOR CUFF INJURIES SHOULDER OSTEOARTHRITIS

Contacts and locations

Locations

Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.