Could CBD be the next painkiller for shoulder surgery patients?
NCT ID NCT06381791
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether Epidiolex (a CBD medicine) can help control pain after shoulder surgery when added to standard painkillers. About 80 adults having rotator cuff repair will take either CBD or a placebo for two weeks after surgery. They will track their pain and medication use daily, and researchers will check for side effects and changes in pain-related disability.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cannabidiol (Epidiolex)
What this could lead to
If it works, this could point toward a safe, non-opioid option for managing pain after orthopedic surgery.
What could go wrong
This is an early-phase trial with only 80 people, so results may not apply to everyone. CBD can cause side effects like drowsiness or liver issues, and it may not reduce pain better than a placebo.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Houston Methodist Hospital
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact