Rotator cuff syndrome

This trial compares two approaches for people with rotator cuff arthropathy, a condition where the shoulder joint wears down due to a torn rotator cuff. One group receives reverse total shoulder replacement surgery followed by standard rehab, while the other group completes a 12-…

This study follows adults who have received a Tipmed shoulder replacement to see how well the implant works and if any problems arise over the first year. Participants have conditions like severe arthritis, rotator cuff damage, or a broken shoulder bone. Researchers track shoulde…

This study is testing a device called the Integrity Implant System to see if it helps people with torn rotator cuffs heal better after surgery. The implant is used to support the repair and reduce the chance of the tear coming back. About 150 adults will take part, and their prog…

This study tests whether removing a small part of the shoulder bone (coracoid) during reverse total shoulder replacement helps patients rotate their arm inward better after surgery. Sixty adults needing shoulder replacement will be randomly assigned to get the standard surgery or…

This study tests whether injections of donated skin cells (TPX-115) can improve shoulder function and reduce pain in people with partial-thickness rotator cuff tears. About 60 adults whose symptoms have lasted over 3 months despite other treatments will receive either the cell th…

This study is tracking up to 400 people who are having arthroscopic rotator cuff repair with a device called the REGENETEN Bioinductive Implant. The implant is placed to support healing of the torn tendon. Researchers will measure shoulder function, pain, and quality of life for …

This study is testing a new device called SINEFIX to repair small rotator cuff tears (up to 2 cm) in the shoulder. About 60 adults who need surgery for this condition will receive the implant. The goal is to see if it improves shoulder function and reduces pain compared to before…

This study tests a new surgical technique for people with massive rotator cuff tears. Instead of cutting the biceps tendon, surgeons move it to help support the repair. The study will follow 35 adults for one year to see if it improves shoulder function, quality of life, and slee…

This study follows 21 adults who previously received an injection of stem cells from donated umbilical cords to treat rotator cuff disease. Researchers want to see if the treatment remains safe and helps with shoulder pain and function over the long term. Participants fill out qu…

This study is checking the long-term safety and how well a medical device called the Pitch-Patch works for people who have had surgery for a torn rotator cuff in the shoulder. The Pitch-Patch is a small polyester patch that helps strengthen the repair. About 37 people who already…

This study tests whether adding a patch made from donated human skin to standard rotator cuff repair surgery can lower the chance of the tendon tearing again. Forty adults aged 50 to 75 with large tears will be randomly assigned to get surgery with or without the patch. An MRI on…

This study follows over 1,000 people who receive a shoulder replacement with FX Shoulder Solutions systems. Researchers will track how often the implant needs to be replaced (revision) and measure pain, movement, and quality of life for up to 10 years after surgery. The goal is t…

This study looks at whether adding a small amount of a patient's own processed fat tissue during arthroscopic rotator cuff repair can improve healing and reduce the chance of the tendon tearing again. About 52 adults with full-thickness tears will be followed for at least 5 years…

This study tests whether stem cells from donated umbilical cords can safely help heal partial rotator cuff tears. 21 adults with shoulder pain for at least 3 months who haven't improved with other treatments will receive a single injection of stem cells into the tear. Researchers…

This study tests whether a special graft made from donated placental tissue, called ActiveMatrix, can help the shoulder tendon heal better after rotator cuff repair surgery. About 72 people with a full-thickness tear in 1 or 2 tendons will be randomly assigned to get either a low…

This study tests whether adding a BioBrace® implant during rotator cuff surgery helps the tendon heal better and reduces the chance of re-tearing. About 268 adults aged 40–70 with full-thickness tears will be randomly assigned to get surgery with or without the implant. The main …

This study tests whether a patch made from donated placental tissue can help rotator cuff tears heal better after surgery. Half of the 120 participants will get the patch along with standard repair, and the other half will get standard repair alone. An MRI one year later will che…

This study is testing a new medical device called the lok™ suture anchor system for repairing torn tendons and labrum in the shoulder. About 216 adults with rotator cuff tears, shoulder instability, or partial tendon avulsions will receive the anchors during surgery. Researchers …

This study tests whether injecting a person's own muscle fibers into the shoulder muscle can safely improve strength and function after rotator cuff repair. Researchers take a small sample of chest muscle, break it into tiny fragments, and inject them into the torn muscle during …

This study looks at whether giving sex hormone therapy to men with low hormone levels can help their shoulder tendons heal better after surgery. About 58 men will receive either hormone pills or a placebo after rotator cuff repair. The goal is to see if the therapy improves tendo…

This study tests whether applying Prontosan antimicrobial gel to the skin during shoulder replacement surgery can reduce bacteria that might cause infections. It involves 60 adult men having their first shoulder replacement. Researchers will compare infection-related bacteria lev…

This early study is testing a new, dissolvable shoulder spacer in 20 people over 50 with large rotator cuff tears. The spacer is placed in the shoulder to reduce friction and pain. Researchers are checking if it is safe and helps improve shoulder function.

This study compares standard rotator cuff surgery to surgery plus a bioinductive patch that aims to help the tendon heal better. About 78 adults with full-thickness tears will be randomly assigned to one of the two groups. The main goal is to see if the patch leads to fewer tendo…

This study compares two versions of a shoulder replacement surgery for people with shoulder arthritis. In one version, surgeons repair a small but important tendon called the subscapularis; in the other, they leave it unrepaired. The goal is to see which approach gives better sho…

This study is testing a shoulder replacement device in 300 people with shoulder arthritis, bone death, or rotator cuff tears. Participants receive the implant and are followed for 10 years to see how well it works and if it is safe. The goal is to improve pain and shoulder functi…

This study tests a new surgical approach for people with large rotator cuff tears. Doctors will use a special skin tissue (donated and processed to remove cells) combined with the patient's own bone marrow and shoulder lining cells to strengthen the repair. The goal is to see if …

This study compares two surgical options for people with large, irreparable rotator cuff tears: partial repair alone versus partial repair plus a tissue graft to rebuild the shoulder capsule. Researchers will track pain, function, and quality of life in 105 participants over two …

This study will follow 600 people who receive an FX artificial shoulder implant for conditions like arthritis, rotator cuff problems, or shoulder fractures. Researchers will measure pain, shoulder function, implant survival, and any complications over time. The goal is to see how…

This study is testing a new type of suture anchor, called ComposiTCP, for repairing torn rotator cuffs in the shoulder. The anchors are used with a special tape to help the soft tissue reattach to bone. Researchers will follow 43 patients for one year to see if the repair holds a…

This study tests a special collagen implant (REGENETEN) for people with partial-thickness rotator cuff tears. The goal is to see if it helps patients return to daily activities faster than the standard surgical repair. About 234 adults who have not improved after 3 months of othe…

This study compares two surgeries for people with large, irreparable rotator cuff tears. One surgery smooths the bone (tuberoplasty), the other places a small balloon spacer under the shoulder. Researchers will track shoulder motion and pain relief in 40 adults to see which appro…

This study tests whether a smartphone app that guides rehabilitation exercises can help people recover shoulder function after rotator cuff repair surgery. Seventy adults who have had the surgery will use either the app or receive standard care with a brochure. The goal is to see…

This study tests a new device called FiberLocker® that reinforces rotator cuff surgery to help the tendon heal better. About 60 adults aged 30-70 with full-thickness tears will be enrolled. The main goal is to see if the repair heals properly on MRI after 6 months, with a focus o…

This study looks at whether using a 10% benzoyl peroxide acne cleanser on the shoulder before surgery can reduce harmful bacteria. About 150 people scheduled for rotator cuff repair will either use the acne wash or their usual soap. Researchers will then check skin and suture sam…

This study is checking how long the Medacta Shoulder System lasts and how well it works in 200 people with shoulder issues like arthritis, fractures, or failed previous shoulder replacements. Participants will be followed over time to measure shoulder function, pain, and movement…

This trial compares two surgical procedures for massive rotator cuff tears: latissimus dorsi tendon transfer and superior capsular reconstruction. 44 adults with massive tears will be randomly assigned to one surgery and followed for 2 years. The goal is to see which operation pr…

This study compares two methods of pulsed radiofrequency treatment for the suprascapular nerve in people with chronic shoulder pain from rotator cuff problems. Thirty-two adults aged 40 to 80 will be randomly assigned to receive the treatment at either the suprascapular notch or …

This study tests whether starting an accelerated shoulder rehabilitation program immediately after reverse total shoulder replacement leads to better pain relief and function than the standard rehab approach. About 74 people with shoulder osteoarthritis will be randomly assigned …

This trial compares two standard anesthesia methods—inhaled sevoflurane versus intravenous propofol—during arthroscopic rotator cuff repair. The goal is to see which one gives surgeons a clearer view inside the shoulder joint, which is important for safety and success. About 110 …

This study tests a hands-on therapy called Mobilization with Movement (MWM) for people with rotator cuff tears. 75 adults with shoulder pain for at least 3 months will be split into three groups: MWM, standard physical therapy, or a control group. Researchers will measure pain, f…

This study looks at whether adding core stabilization exercises to standard physical therapy can reduce pain and improve shoulder function in people aged 40-60 with partial rotator cuff tears. About 69 participants will be assigned to either core exercises or traditional trunk an…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study looks at whether using a blood flow restriction cuff during exercise can help reduce pain in people with rotator cuff-related shoulder pain. 30 adults will try four different exercise routines with varying cuff pressures to see which works best for pain relief. The goa…

This study tests whether adding pain neuroscience education (PNE) to standard rehab improves pain, movement, and fear of movement in 45 adults aged 40-75 recovering from rotator cuff surgery. Participants are split into three groups: standard rehab alone, standard rehab plus PNE …

This study looks at whether motor imagery training — mentally practicing movements without actually moving — can reduce pain, improve shoulder function, and lessen fear of movement in people with partial rotator cuff tears. About 80 adults will be randomly assigned to either stan…

This study tests a new exercise approach for people with long-term shoulder pain caused by rotator cuff problems. Instead of just doing standard shoulder exercises, participants will also perform movements that shift their focus away from the shoulder. The goal is to see if this …

This study tests whether doing mental tasks while performing shoulder exercises can improve pain and function better than standard exercises alone. 46 adults with chronic shoulder pain from rotator cuff issues will participate in a 6-week program. Researchers will measure pain, s…

This study tests whether Epidiolex (a CBD medicine) can help control pain after shoulder surgery when added to standard painkillers. About 80 adults having rotator cuff repair will take either CBD or a placebo for two weeks after surgery. They will track their pain and medication…

This study tests whether using cold and compression after rotator cuff repair surgery reduces pain better than standard care. About 90 adults with partial or full-thickness rotator cuff tears will be randomly assigned to either a cold/compression device or usual care. Pain levels…

This study looks at whether a digital platform called Band Connect helps people recovering from shoulder surgery or rotator cuff repair do their home exercises more consistently. About 500 adults aged 18 to 89 will use the platform, and researchers will track how many exercises t…

This study compares two types of anesthesia for rotator cuff repair surgery: general anesthesia combined with local anesthesia versus local anesthesia alone. The goal is to see which approach leads to faster recovery and readiness to leave the recovery room. About 34 adults with …

This study compares a wearable device-based remote rehabilitation system to traditional in-person therapy for people recovering from rotator cuff surgery. 72 adults with small to medium tears will be randomly assigned to either group. The goal is to see if the wearable approach c…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests whether adding shock wave therapy to a standard exercise program can reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Fifty adults aged 30 to 55 with chronic shoulder pain will receive either exercises alone or exercises plus sh…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests a minimally invasive procedure called transcatheter arterial embolization (TAE) combined with physical therapy for people with chronic shoulder pain from rotator cuff tendinopathy that hasn't improved with standard treatments. About 41 adults with moderate to sev…

This study tests whether adding an injection called Tropho Tend to standard physical therapy helps reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Sixty adults with shoulder pain lasting at least six weeks will be randomly assigned to receive e…

This study tests whether a special cold compression machine works better than regular ice packs for pain and swelling after arthroscopic rotator cuff repair. About 100 adults having this shoulder surgery will be randomly assigned to one of the two cooling methods. The goal is to …

This study tests whether adding a long-acting painkiller (liposomal bupivacaine) to a standard steroid injection during shoulder surgery can improve recovery for people with rotator cuff tears and shoulder stiffness. About 70 adults will be randomly assigned to receive either the…

This study compares two ways of managing rotator cuff tendinopathy, a common cause of shoulder pain. One group gets monthly check-ups for three months with treatment adjustments as needed, while the other follows standard care. Researchers want to see if the tighter follow-up lea…

This study looks at which pain control method works best after rotator cuff repair surgery. Researchers will compare different combinations of pain medicines to see which reduces the need for strong narcotics like oxycodone. About 130 adults having shoulder surgery will take part…

This study compares two treatments for shoulder pain caused by arthritis or rotator cuff problems: a steroid injection into the joint versus a nerve block. Forty adults with shoulder arthritis will be randomly assigned to one of the two treatments. Researchers will track pain lev…

This study looks at whether teaching people about their rotator cuff-related shoulder pain can reduce symptoms without other treatments. Researchers will track pain levels and knowledge in 116 adults aged 18-65. The goal is to find out which patients improve most from education a…

This study compares online physiotherapy (telerehabilitation) with standard in-person sessions for people who have had arthroscopic rotator cuff repair surgery. The goal is to see if the online option works just as well for reducing pain, improving shoulder movement, and helping …

This study looks at whether 8 weeks of kettlebell training can reduce pain and improve shoulder function better than standard rehab. It involves 38 adults with rotator cuff-related shoulder pain who have been active in sports for at least 3 years. Participants will be randomly as…

This study compares four non-surgical treatments for a common shoulder tendon injury (supraspinatus tear) that causes pain and sleep problems. The treatments include a steroid injection, a nerve block, platelet-rich plasma (PRP), and rehabilitation. Researchers will track pain, s…

This study tests whether a special laser (LightForce) can reduce shoulder pain caused by inflammation from conditions like impingement or rotator cuff tendinitis. About 130 adults with pain lasting over 3 months will get either real laser or a sham laser, plus standard physiother…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study looks at whether releasing a small chest muscle (pectoralis minor) during reverse shoulder replacement helps reduce pain and improve arm movement. About 90 adults getting this surgery will be randomly assigned to have the muscle released or not. Researchers will compar…

This study compares two non-surgical treatments for rotator cuff syndrome, a common cause of shoulder pain. Researchers will test if video game-based exercises or body awareness therapy better reduce pain and improve movement. 66 adults with partial rotator cuff tears will partic…

This study investigates whether tightness in the pectoralis minor, a small chest muscle, is linked to partial rotator cuff tears in the shoulder. Researchers will compare 45 patients with tears to 45 without, matching them by age, sex, body size, and dominant side. Using simple m…

This study looks at how wearing a shoulder sling changes the way people move and keep their balance during everyday activities like walking or climbing stairs. Researchers will track 30 people—some with shoulder injuries and some healthy—using motion-capture cameras. The goal is …

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study follows 500 people who are already scheduled for routine shoulder or knee surgery for sports injuries. Researchers will track their recovery over two years using questionnaires about pain and function. The goal is to find out which factors—like injury type or surgical …

This study follows 150 adults with rotator cuff-related shoulder pain who are treated without surgery, such as with physiotherapy or pain relief. Participants fill out questionnaires about pain, disability, and quality of life at the start and after six months. The goal is to ide…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study explores whether high-intensity interval training (HIIT) is a feasible and acceptable option for people with long-term shoulder pain, such as rotator cuff issues or frozen shoulder. Researchers will enroll 15 people with shoulder pain and 15 without, measuring inflamma…

This study is collecting DNA and MRI data from 3,500 adults aged 40 to 85 to find genetic variations linked to rotator cuff tears. Researchers will compare people with and without tears to identify risk genes. The goal is to better understand why tears happen and why some treatme…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study looks at why exercise helps some people with shoulder pain from rotator cuff tendinopathy but not others. Researchers will use brain scans to see how exercise changes the brain and find out who is most likely to get better. The goal is to make exercise treatments more …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study is tracking 20,000 people who have had or will have shoulder replacement surgery to see how well the implants work over at least 10 years. Researchers will measure pain, daily function, and strength using standard shoulder scores. The goal is to better understand the l…

This study looks at whether sarcopenia (age-related muscle loss) influences the type and location of rotator cuff tears. Researchers will assess muscle health in 104 adults aged 40-75 with shoulder problems using ultrasound and strength tests, then compare their MRI scans to see …

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study tests whether text messaging can help collect feedback from orthopedic patients about their recovery. Researchers will enroll up to 3,000 people with specific bone or spine injuries. The goal is to use this information to schedule clinic visits more efficiently, so pat…

This study observes 60 adults having shoulder surgery to see how often a common nerve block (interscalene brachial plexus block) causes temporary paralysis of the diaphragm, the main breathing muscle. Participants are split into three groups receiving different types of local ane…

This observational study will examine the relationship between core stability and reaction time, hand-eye coordination, pain, and function in 52 people with rotator cuff lesions, comparing them to healthy individuals. Participants will undergo various endurance and strength tests…

This study is testing a new physical therapy protocol for people over 50 who have had arthroscopic rotator cuff surgery. Researchers will track shoulder function, pain levels, and sleep quality over the recovery period. The goal is to gather better evidence on what helps patients…

This study looks at how the size and type of rotator cuff tear affects the suprascapular nerve in the shoulder. Researchers will use MRI scans and nerve tests on 250 adults to see which tears cause nerve damage. They also want to find out if surgical repair can help the nerve rec…