Placental graft could boost shoulder surgery success

NCT ID NCT05894265

Recruiting now Disease control Sponsor: The University of Texas Health Science Center, Houston Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a special graft made from donated placental tissue, called ActiveMatrix, can help the shoulder tendon heal better after rotator cuff repair surgery. About 72 people with a full-thickness tear in 1 or 2 tendons will be randomly assigned to get either a low or high dose of the graft, or a plain saline injection during surgery. The main goal is to see if the graft leads to a more intact tendon on MRI and better shoulder movement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ActiveMatrix (human placental connective tissue-derived allograft)
What this could lead to: If it works, this could lead to a better healing and recovery after rotator cuff surgery, reducing the chance of re-tear.
What could go wrong: This is a small, early pilot study, so results may not apply to everyone. The graft might not improve healing more than standard care, and there are risks from surgery itself.

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Conditions

The condition(s) this trial relates to.

Rotator Cuff Injuries rotator cuff syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ROTATOR CUFF TEARS

Contacts and locations

Locations

The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States

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