Placental graft could boost shoulder surgery success
NCT ID NCT05894265
First seen May 14, 2026 · Last updated Jun 23, 2026 · Updated 8 times
Summary
This study tests whether a special graft made from donated placental tissue, called ActiveMatrix, can help the shoulder tendon heal better after rotator cuff repair surgery. About 72 people with a full-thickness tear in 1 or 2 tendons will be randomly assigned to get either a low or high dose of the graft, or a plain saline injection during surgery. The main goal is to see if the graft leads to a more intact tendon on MRI and better shoulder movement.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The University of Texas Health Science Center at Houston
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ActiveMatrix (human placental connective tissue-derived allograft)
What this could lead to
If it works, this could lead to a better healing and recovery after rotator cuff surgery, reducing the chance of re-tear.
What could go wrong
This is a small, early pilot study, so results may not apply to everyone. The graft might not improve healing more than standard care, and there are risks from surgery itself.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.