Can a donor skin patch stop rotator cuff tears from coming back?

NCT ID NCT04975581

Recruiting now Disease control Sponsor: University Hospitals, Leicester Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding a patch made from donated human skin to standard rotator cuff repair surgery can lower the chance of the tendon tearing again. Forty adults aged 50 to 75 with large tears will be randomly assigned to get surgery with or without the patch. An MRI one year later will check for re-tears.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: human dermal matrix allograft (processed skin graft from a human donor)
What this could lead to: If it works, this could reduce the chance of rotator cuff re-tear after surgery, improving shoulder function and avoiding repeat operations.
What could go wrong: This is a small pilot study with only 40 participants, so results may not apply to everyone. The patch is from human donors, which carries a small risk of infection or rejection.

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Conditions

The condition(s) this trial relates to.

Rotator Cuff Injuries rotator cuff syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ROTATOR CUFF TEARS

Contacts and locations

Locations

University Hopsitals of Leicester NHS Trust
RECRUITING

Leicester, United Kingdom

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