University Hospitals, Leicester

This study tests whether adding a patch made from donated human skin to standard rotator cuff surgery can lower the chance of the tendon tearing again. Forty adults aged 50 to 75 with large tears will be randomly assigned to get surgery with or without the patch. An MRI one year …

This study compares a new pacing technique (His bundle pacing) to standard right ventricular pacing in 100 adults with symptomatic atrial fibrillation and heart failure who are having AV node ablation. The goal is to see if the new method helps them walk farther, feel better, and…

This study tests a blood filter called HA380 in 40 critically ill adults (ages 18-65) who need dialysis or ECMO due to severe infection, injury, or major surgery. The filter is added to their life-support circuit to remove inflammatory substances from the blood. Researchers want …

This study tracks RSV (respiratory syncytial virus) in UK children under 2, after COVID-19 restrictions caused RSV to disappear and then return in unusual patterns. Researchers collect data from emergency departments on bronchiolitis cases, including severity and treatments neede…

This study aims to understand why breathlessness varies among people with different lung diseases like COPD, asthma, and ILD. Researchers will measure lung function, exercise ability, and breathing patterns in 75 participants (50 with lung disease and 25 healthy controls). The go…

This study is testing a simple bedside device called a bioimpedance analyser to measure body water changes in pregnant women. Researchers will compare its readings to standard fluid charts in 900 women, including those having planned C-sections, induced labor, or conditions like …

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study aims to find the genetic causes of bicuspid aortic valve (BAV), a common heart defect where the valve has two flaps instead of three. Researchers will collect blood samples from 700 people with BAV and their family members to compare DNA. The goal is to identify gene c…