Hunt for heart valve genes launches in 700 volunteers

NCT ID NCT04514445

Recruiting now Knowledge-focused Sponsor: University Hospitals, Leicester Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to find the genetic causes of bicuspid aortic valve (BAV), a common heart defect where the valve has two flaps instead of three. Researchers will collect blood samples from 700 people with BAV and their family members to compare DNA. The goal is to identify gene changes linked to the condition, which could lead to better understanding and future treatments.

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Conditions

The condition(s) this trial relates to.

aortic valve disease 1 cardiovascular disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCULAR DISEASES

Contacts and locations

Locations

Imperial College Healthcare NHS Trust
RECRUITING

London, United Kingdom
Kettering General Hospital
RECRUITING

Kettering, United Kingdom
Sheffield Teaching Hospital NHS Foundation Trust
RECRUITING

Sheffield, United Kingdom
University Hospitals of Leicester
RECRUITING

Leicester, United Kingdom

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