Can a new device suck out deadly lung clots?

NCT ID NCT06062329

Completed Disease control Sponsor: Imperative Care, Inc. Source: ClinicalTrials.gov ↗

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This trial tests a device called the Symphony Thrombectomy System in people with acute pulmonary embolism, a condition where blood clots block arteries in the lungs. The device is designed to restore blood flow by suctioning out or breaking up the clots. The study will check how safe the device is and whether it reduces strain on the heart, as seen on CT scans, within 48 hours of the procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Symphony Thrombectomy System, a device that removes blood clots from the lungs using aspiration and mechanical clot engagement
What this could lead to: If successful, this device could offer a new way to quickly clear life-threatening blood clots in the lungs, potentially reducing complications and improving recovery for people with acute pulmonary embolism.
What could go wrong: This is an early-stage trial with a moderate number of participants, so the device may not prove safer or more effective than existing treatments. There are risks of bleeding, device-related injury, or other serious adverse events.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Embolism pulmonary embolism Thromboembolism thrombotic disease vascular disorder venous thromboembolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE PULMONARY EMBOLISM CARDIOVASCULAR DISEASES EMBOLI, PULMONARY EMBOLISM THROMBOEMBOLISM THROMBOSIS THROMBUS; EMBOLISM VASCULAR DISEASES

Contacts and locations

Locations

Ascension St John Hospital

Detroit, Michigan, 48236, United States
Bon Secours Mercy Health, Inc

Cincinnati, Ohio, 45237, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Corewell Health

Grand Rapids, Michigan, 49503, United States
Emory University

Atlanta, Georgia, 30322, United States
Endeavor Health

Glenview, Illinois, 60026, United States
First Coast Cardiovascular Institute

Jacksonville, Florida, 32256, United States
Huntsville Hospital

Huntsville, Alabama, 35801, United States
Icahn School of Medicine at Mount Sinai

New York, New York, 10029, United States
Indiana University

Indianapolis, Indiana, 46202, United States
Medical City Dallas Hospital

Dallas, Texas, 75230, United States
Medical City Fort Worth Hospital

Fort Worth, Texas, 76104, United States
NYU Grossman School of Medicine

New York, New York, 10016, United States
Northwell Health

Mount Kisco, New York, 10549, United States
Prisma Health

Greenville, South Carolina, 29605, United States
Sentara Norfolk General Hospital

Norfolk, Virginia, 23507, United States
Tallahassee Memorial Hospital

Tallahassee, Florida, 32308, United States
The Heart Hospital Baylor Plano

Plano, Texas, 75093, United States
William Beaumont Hospital - Royal Oak

Royal Oak, Michigan, 48073, United States

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