Rotator cuff syndrome

This early-stage trial is testing a new non-degradable shoulder spacer in people over 50 with massive rotator cuff tears. The spacer is designed to be placed in the shoulder to help improve pain and function. The study will look at how safe the device is and whether it helps with…

This trial tests whether injecting tranexamic acid into the shoulder bone before rotator cuff repair improves the surgeon's view during the procedure. Sixty adults scheduled for arthroscopic rotator cuff repair will receive either the drug or a placebo. The goal is to see if this…

This study compares three different schedules of shock wave therapy for people with partial rotator cuff tears, a common cause of shoulder pain and limited movement. The goal is to see if a high-frequency, short-course treatment (daily sessions for one week) works as well as or b…

This trial tests whether an injection of platelet-rich plasma (PRP) made from a patient's own blood can help heal partial tears of the supraspinatus tendon in the shoulder. One hundred adults with confirmed tears will receive either PRP plus standard physical therapy or therapy a…

This trial tests whether using a piece of the patient's own biceps tendon as a graft can improve rotator cuff repair and reduce the risk of re-tear. About 90 working-age adults with supraspinatus tears will be randomly assigned to either standard arthroscopic repair or repair wit…

This study tests whether injecting a patient's own fat-derived stem cells into the shoulder muscle, alongside standard surgery, improves healing for torn rotator cuffs. Thirty adults with a confirmed tear will be randomly assigned to surgery alone or surgery plus stem cell inject…

This study tests whether injecting stem cells from umbilical cords can help heal partial rotator cuff tears in the shoulder. Thirty-eight adults with ongoing shoulder pain will receive either a high or medium dose of stem cells or a placebo. The main goal is to see if the tear sh…

This study looks at whether adding stem cells from the shoulder bursa and platelet-rich plasma (PRP) to standard rotator cuff repair helps the tendon heal better. About 200 adults with full-thickness supraspinatus tears will be followed for a year. Researchers will compare those …

This study tests whether using a piece of the patient's own biceps tendon as a patch during rotator cuff repair helps the torn tendon heal better. 80 adults with medium to large tears will be randomly assigned to standard repair or repair with the patch. Researchers will measure …

This study looks at three ways to treat a specific type of shoulder fracture (greater tuberosity fracture) that also involves a rotator cuff injury. The three options are: non-surgical care, surgery right away, or surgery after a delay. The goal is to see which approach leads to …

This study looks at whether estradiol patches can improve shoulder healing after rotator cuff repair in post-menopausal women. About 58 women will receive either an estradiol patch or a placebo patch for three months after surgery. The goal is to see if the hormone helps reduce p…

This study compares a telerehabilitation system called Band Connect to standard in-person physical therapy for people recovering from rotator cuff repair surgery. The Band Connect uses smart handles and resistance bands that connect to a phone app to guide exercises and track pro…

This early-phase trial tests whether tendon stem cells can help rotator cuff tears heal better after surgery. About 107 adults with small to medium tears will receive either standard repair or repair plus stem cells placed at the injury site. The study will check for side effects…

This study will check if a new physical exam called Said's test can accurately diagnose biceps tendon injuries in the shoulder. Researchers will test 144 adults, including those with shoulder injuries and healthy volunteers. Two doctors will perform the new test and standard test…

Shoulder surgery often causes severe pain, and a nerve block is commonly used to numb the area. However, when the block wears off, many patients experience sudden intense 'rebound pain.' This trial tests whether a single-shot nerve block combined with an intravenous dose of the s…

This study compares giving a nerve block before versus after arthroscopic rotator cuff repair surgery to see which timing provides better pain control and recovery. Participants are adults undergoing this shoulder surgery who receive an interscalene nerve block. The trial measure…

This study looks at whether adding a specific hands-on technique called Mobilization With Movement (MWM) to standard exercises can better reduce pain and improve shoulder function in people with rotator cuff tendinopathy. About 60 adults with chronic shoulder pain will be split i…

This study compares two manual therapy techniques—myofascial trigger point release and the Neil Asher Technique—for treating rotator cuff syndrome, a common cause of shoulder pain and limited movement. Thirty-six adults aged 40 to 60 with mild to moderate rotator cuff syndrome wi…

This study looks at whether 4 weeks of low-intensity shoulder exercises, done with or without a blood flow restriction cuff, can reduce pain and improve function in people with rotator cuff-related shoulder pain. 34 adults with long-lasting shoulder pain will be randomly assigned…

This study tests a new type of nerve block (PENG block) for people with chronic shoulder pain that hasn't improved with other treatments. 45 adults will get an ultrasound-guided injection of numbing medicine and steroid. Researchers will measure pain, shoulder function, and satis…

This study tests whether adding high-intensity laser therapy to standard physical therapy helps people recover better after arthroscopic rotator cuff repair. 46 adults aged 30-70 with shoulder pain will be randomly assigned to receive either real laser therapy or a sham treatment…

This study tests whether a mobile app with AI-guided exercise videos and reminders helps people recover better after arthroscopic rotator cuff repair compared to standard paper instructions. About 102 adults who need surgery will be randomly assigned to use the app or follow pape…

This study tests whether adding a gentle back-mobilization technique to standard shoulder therapy can improve pain, movement, and function in people with rotator cuff injuries. Forty adults with chronic shoulder pain will receive either shoulder mobilization alone or combined wit…

This study tests whether a special device called H-Wave can help people recover faster and with less pain after rotator cuff repair surgery. About 80 adults aged 18-64 will either receive standard care or standard care plus the H-Wave device. Researchers will track pain, medicati…

This study tests whether a home-based virtual reality (VR) exercise program is practical and helpful for people with shoulder pain lasting more than three months. Thirty adults aged 16 and older with rotator cuff syndrome, frozen shoulder, or shoulder instability will use a VR he…

This study compares two surgical techniques for the biceps tendon—tenotomy (cutting the tendon) and tenodesis (reattaching it)—in 50 adults aged 50-70 undergoing rotator cuff repair. The goal is to see which method leads to less pain, better shoulder function, and stronger grip a…

This study looks at whether using a pillow placed behind the shoulder after rotator cuff repair surgery can lower pain and improve sleep. About 126 adults aged 40 to 70 will choose whether to use the pillow or not. Their pain, sleep quality, and shoulder function will be checked …

This study looks at whether teaching people with rotator cuff syndrome the best sleeping positions can improve their sleep quality while they undergo physical therapy. Researchers will compare two groups: one getting standard physical therapy, and another getting physical therapy…

This study looks at whether starting gentle shoulder exercises soon after rotator cuff repair leads to better recovery than waiting six weeks. About 86 adults who have surgery for a torn rotator cuff will be randomly assigned to either early or delayed rehabilitation. Researchers…

This study looks at whether doing extra tissue release during arthroscopic rotator cuff repair can prevent shoulder stiffness after surgery. About 50 adults with small-to-medium rotator cuff tears will be randomly assigned to get either the standard repair or the repair plus extr…

This study tests four different virtual reality (VR) exercises in 30 adults who have had rotator cuff-related shoulder pain for at least 6 months. Participants will do weekly VR sessions for four weeks and complete questionnaires about their arm function, pain, and fear of moveme…

This study tests a special brace with a built-in pillow to see if it helps people sleep better after rotator cuff surgery. About 100 patients will either use the pillow brace or a standard brace. The goal is to reduce nighttime pain and improve sleep quality, which may help recov…

This study will follow 50 adults having arthroscopic rotator cuff repair to see if a condition called central sensitization—where the nervous system is overly sensitive to pain—affects their recovery. Before surgery and 3 months after, researchers will measure pain and shoulder f…

This study will use portable ultrasound to measure the thickness of forearm muscles and tendons in 90 adults with rotator cuff-related shoulder pain. Researchers want to see if these measurements change based on how long someone has had shoulder pain. They will also measure hand …

This study looks at whether 'central sensitization' — a condition where the nervous system is overly sensitive to pain — affects how well physical therapy works for people with partial rotator cuff tears. Researchers will follow 60 adults aged 18-65 who have had shoulder pain for…

This study looks at how stress on the shoulder bone (acromion) changes after reverse shoulder replacement surgery. Researchers will use CT and MRI scans from 13 patients to create computer models that show where bone stress is highest. The goal is to better understand and prevent…

This study looks at two different ways to perform reverse total shoulder replacement in 130 people aged 60-85 with severe shoulder arthritis and torn rotator cuffs. The goal is to see which technique leads to better muscle activity and arm movement. Participants will have their s…

This study looks at whether metabolic syndrome (a cluster of conditions like high blood pressure and excess belly fat) makes it harder to recover from a rotator cuff injury. Forty adults with rotator cuff tears will be split into two groups—those with and without metabolic syndro…

This study looks at how having a structured, values-based conversation affects people's decisions about diagnostic imaging tests for common musculoskeletal conditions like arthritis, carpal tunnel syndrome, and tendon problems. About 220 adults from a specialty clinic will read a…