The Methodist Hospital Research Institute

This early-stage study is testing the safety and initial effectiveness of combining two drugs, olaparib and vorinostat, for adults with advanced breast cancer that has returned after treatment or spread. The goal is to find the safest dose and see if blocking two cancer cell repa…

This study is testing if giving an immunotherapy drug called atezolizumab before surgery is safe for people with high-risk skin melanoma that hasn't spread. The drug aims to help the patient's own immune system fight the cancer, potentially lowering the chance of it coming back a…

This study is testing if a drug called belumosudil can prevent harmful scarring inside newly transplanted kidneys. The trial will involve 40 people who recently received a kidney transplant. Participants will receive either the study drug or a placebo, in addition to their standa…

This study is testing a new two-part treatment for muscle-invasive bladder cancer in patients who cannot receive standard chemotherapy. Before having their bladder surgically removed, participants receive a drug called sasanlimab (an immunotherapy) and a short, precise course of …

This study is testing if injecting an antibiotic directly into the shoulder bone during replacement surgery is as effective as the standard method of giving it through an IV. Researchers are comparing the two methods in 33 patients to see if both deliver similar antibiotic levels…