The Methodist Hospital Research Institute

This phase 2 trial tests whether adding the immunotherapy drug durvalumab to two standard targeted drugs (trastuzumab and pertuzumab) can shrink tumors more effectively in people with HER2-enriched breast cancer. The study involves 51 participants and measures how many have no or…

This study tests whether adding a blood flow restriction (BFR) cuff to standard physical therapy helps people recover better after wrist fracture surgery. The cuff is placed on the arm during low-intensity exercises to mimic the effects of high-intensity training. Researchers wil…

This early-stage trial tests the safety of combining two drugs, olaparib and vorinostat, in people with advanced breast cancer that has returned or spread. About 28 participants will receive the combination to find the best dose and check for side effects. The goal is to see if t…

This early-phase trial is testing whether the immunotherapy drug atezolizumab (Tecentriq) is safe to use before surgery in people with high-risk melanoma that hasn't spread. The study includes 20 participants and focuses on whether the treatment causes side effects that delay the…

This phase 2 trial tests whether adding belumosudil (Rezurock) to standard care can prevent scarring in new kidney transplants. About 40 adults receiving their first or second kidney will be randomly assigned to get the drug or a placebo for a year. The study tracks serious side …

This phase II trial tests a combination of an immunotherapy drug called sasanlimab and focused radiation given before bladder removal surgery in 33 patients with muscle-invasive bladder cancer who cannot take standard chemotherapy. The goal is to see if this approach is safe, fea…

This study tests whether injecting the antibiotic vancomycin directly into the shoulder bone works as well as giving it through a vein during shoulder replacement surgery. About 33 adults having shoulder replacement will be split into two groups to compare antibiotic levels in bo…

This study tests whether using a lower-pressure tourniquet during orthopedic surgeries can reduce pain and the need for opioid painkillers afterward. Standard tourniquets use high pressure, which can cause muscle weakness and pain. The experimental device sets pressure based on t…