New Triple-Drug attack shows promise against aggressive breast cancer

NCT ID NCT03820141

First seen Apr 28, 2026 · Last updated May 15, 2026 · Updated 3 times

Summary

This study tests whether adding an immunotherapy drug (durvalumab) to two standard HER2-targeted drugs (trastuzumab and pertuzumab) can shrink tumors more effectively in women with a specific, aggressive type of breast cancer called HER2-enriched. About 51 women with early-stage, hormone-receptor-negative breast cancer will receive the combination before surgery. The main goal is to see how many patients have little or no cancer remaining in the breast after treatment.

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Contacts and locations

Locations

  • Houston Methodist Cancer Center

    Houston, Texas, 77030, United States

Conditions

Explore the condition pages connected to this study.