Could a simple tourniquet change cut Post-Surgery pain and opioid use?

NCT ID NCT04390425

Ongoing Symptom relief Sponsor: The Methodist Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using a lower-pressure tourniquet during orthopedic surgeries can reduce pain and the need for opioid painkillers afterward. Standard tourniquets use high pressure, which can cause muscle weakness and pain. The experimental device sets pressure based on the patient's blood pressure plus a safety margin. Researchers are enrolling 400 adults undergoing common procedures like knee replacement or carpal tunnel release.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Limb occlusion pressure tourniquet (device)
What this could lead to: If it works, this could offer a simple way to reduce pain and opioid use after common orthopedic surgeries.
What could go wrong: This is a mid-sized study testing a device modification, not a new drug. The benefit may be small or not apply to all surgeries.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

carpal tunnel syndrome cubital tunnel syndrome osteoarthritis, hand osteoarthritis, knee radius fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LIMB OCCLUSION PRESSURE

Contacts and locations

Locations

Houston Methodist Hospital

Houston, Texas, 77030, United States

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