Could a simple tourniquet change cut Post-Surgery pain and opioid use?
NCT ID NCT04390425
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether using a lower-pressure tourniquet during orthopedic surgeries can reduce pain and the need for opioid painkillers afterward. Standard tourniquets use high pressure, which can cause muscle weakness and pain. The experimental device sets pressure based on the patient's blood pressure plus a safety margin. Researchers are enrolling 400 adults undergoing common procedures like knee replacement or carpal tunnel release.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Limb occlusion pressure tourniquet (device)
What this could lead to
If it works, this could offer a simple way to reduce pain and opioid use after common orthopedic surgeries.
What could go wrong
This is a mid-sized study testing a device modification, not a new drug. The benefit may be small or not apply to all surgeries.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Houston Methodist Hospital
Houston, Texas, 77030, United States