Direct brain infusion trial offers new hope for kids with relapsed glioma

NCT ID NCT05956821

First seen Dec 16, 2025 · Last updated Jun 18, 2026 · Updated 28 times

Summary

This study tests whether giving two drugs (cetuximab and bevacizumab) directly into the brain's blood vessels each month is safe and can shrink tumors or slow their growth. It includes children and young adults under 22 with certain types of brain tumors that have come back or not responded to standard treatment. The goal is to control the disease, not cure it, and participants will be closely monitored for side effects and tumor response.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Jackson Memorial Hospital

    RECRUITING

    Miami, Florida, 33136, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

Conditions

The condition(s) this trial relates to.

anaplastic astrocytoma anaplastic oligoastrocytoma astrocytoma (excluding glioblastoma) childhood brain stem neoplasm diffuse intrinsic pontine glioma diffuse midline glioma, H3 K27M-mutant fibrillary astrocytoma glioblastoma glioma susceptibility 1 oligodendroglioma pilomyxoid astrocytoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.