Could skipping radiation help elderly brain cancer patients live longer with fewer side effects?

NCT ID NCT04765514

Recruiting now Disease control Sponsor: AHS Cancer Control Alberta Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing whether chemotherapy alone (temozolomide) works as well as the standard combination of chemotherapy plus radiation for elderly and frail patients with newly diagnosed glioblastoma. The study aims to enroll 107 patients aged 65 and older with poor performance status. If chemotherapy alone proves non-inferior, it could offer a less toxic and more convenient treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Temozolomide (chemotherapy)
What this could lead to: If successful, this could show that chemotherapy alone is a safe and effective option for elderly glioblastoma patients, avoiding the added side effects of radiation.
What could go wrong: This is a small, early-phase trial (107 people) comparing two treatments, not testing a new drug. It may not prove that chemotherapy alone is better or equal, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for GLIOBLASTOMA MULTIFORME are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

glioblastoma glioma susceptibility 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA MULTIFORME

Contacts and locations

Locations

Arthur J.E. Child Comprehensive Cancer Center (formerly Tom Baker Cancer Centre)
TERMINATED

Calgary, Alberta, Canada
Cross Cancer Institute
RECRUITING

Edmonton, Alberta, T6G 1Z2, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.