New combo tackles recurrent brain tumor: immunotherapy plus radiation before surgery
NCT ID NCT04977375
First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This early-phase trial is testing whether combining an immunotherapy drug (pembrolizumab) with targeted radiation before surgery is safe and feasible for people with recurrent glioblastoma, an aggressive brain cancer. Ten participants will receive the drug and radiation, then undergo standard surgery to remove the tumor. Researchers will monitor side effects and overall survival to see if this approach warrants further study.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pembrolizumab (an immunotherapy drug that helps the immune system fight cancer)
- What this could lead to
- If this approach is safe and shows promise, it could point toward a new treatment option for recurrent glioblastoma, a brain cancer with few effective therapies.
- What could go wrong
- This is a very early, small trial (only 10 participants) focused on safety, not effectiveness. The combination may cause serious side effects or fail to improve survival. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
Contact
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