Engineered immune cells take on deadly brain cancer
NCT ID NCT05353530
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests a new therapy made from a patient's own immune cells, modified to better target and attack glioblastoma and other high-grade gliomas. The cells are designed to recognize a protein called CD70 found on these tumors. The main goals are to see if the treatment is safe and possible to deliver in a small group of adults and children.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
8R-70CAR T cells (a type of immune cell modified to target CD70 on tumor cells)
What this could lead to
If successful, this could point toward a new treatment option for glioblastoma and other aggressive brain tumors that are hard to treat.
What could go wrong
This is an early phase 1 trial with only 39 participants, so it is primarily testing safety, not effectiveness. The treatment may cause serious side effects or fail to control the tumor.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Florida Health
RECRUITINGGainesville, Florida, 32608, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••