New hope for kids with aggressive brain cancer: targeted drug combo trial launches
NCT ID NCT05843253
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding two different drug combinations after radiation can help children and young adults (up to age 21) with high-grade gliomas, including DIPG, live longer. One group receives ribociclib plus everolimus; another gets ribociclib plus temozolomide. The goal is to see if these targeted therapies can slow tumor growth and improve survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago
RECRUITINGChicago, Illinois, 60611, United States
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C.S. Mott Children's Hospital
RECRUITINGAnn Arbor, Michigan, 48109, United States
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Children's Hospital Colorado
NOT_YET_RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's National Medical Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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Dana-Farber Cancer Institute
NOT_YET_RECRUITINGBoston, Massachusetts, 02215, United States
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Duke University Health System
RECRUITINGDurham, North Carolina, 27708, United States
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Great Ormond Street Hospital
NOT_YET_RECRUITINGLondon, WC1N 3JH, United Kingdom
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Hopp Children's Cancer Center at NCT Heidelberg (KiTZ)
NOT_YET_RECRUITINGHeidelberg, Baden-Wurttemberg, 69120, Germany
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Montreal Children's Hospital
NOT_YET_RECRUITINGMontreal, Quebec, H4A3J1, Canada
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Nationwide Children's Hospital
RECRUITINGColumbus, Ohio, 43235, United States
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Perth Children's Hospital
RECRUITINGPerth, Western Australia, 6000, Australia
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Queensland Children's Hospital
RECRUITINGSouth Brisbane, Queensland, 4101, Australia
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Royal Children's Hospital
RECRUITINGMelbourne, Victoria, 3052, Australia
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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Starship Children's Hospital
NOT_YET_RECRUITINGAuckland, Grafton, 1023, New Zealand
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Sydney Children's Hospital
RECRUITINGRandwick, New South Wales, 2031, Australia
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Texas Children's Hospital
RECRUITINGHouston, Texas, 77030, United States
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The Hospital for Sick Children (SickKids)
NOT_YET_RECRUITINGToronto, Ontario, M5G1X8, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New imaging clues could sharpen brain tumor monitoring
- Can a virus injected into brain tumors fight recurrence?
- Could cutting a wider margin around brain tumors extend survival?
- Can a Tumor's genetic blueprint guide better treatment for kids with brain cancer?
- Can engineered immune cells tackle an incurable childhood brain tumor?