GLIOBLASTOMA MULTIFORME

This study is testing whether adding the antiviral drug valganciclovir to standard glioblastoma treatment helps patients live longer. It involves 220 adults with newly diagnosed glioblastoma who will receive either the antiviral or a placebo alongside their standard chemotherapy …

This is an early-stage study to test the safety and find the right dose of an experimental oral drug called DSP-0390. It is for adults whose aggressive brain tumors (high-grade gliomas) have come back after previous treatment. The main goals are to see how safe the drug is and ho…

This early-stage study is testing a new antibody drug called APX005M in children and young adults with brain tumors that have come back or are not responding to treatment, or with a newly diagnosed aggressive brain stem glioma. The main goal is to find the safest dose and underst…

This study is testing whether adding an experimental drug called BPM31510 to standard radiation and chemotherapy can help people with newly diagnosed glioblastoma, an aggressive brain cancer. The main goal is to see if this combination can delay cancer progression and extend surv…

This trial is testing whether adding an experimental drug called LAM561 to standard treatment helps people newly diagnosed with an aggressive brain cancer called glioblastoma. About 144 participants will receive either LAM561 or a placebo pill along with their standard radiation …

This study is testing whether an oral cancer drug called ribociclib can get into the brain and reach recurrent brain tumors. It involves 48 adults with recurrent high-grade glioma or meningioma who are scheduled for surgery. Patients take the drug for a short time before their op…

This early-stage trial is testing if adding high-dose vitamin C (given by IV) and an iron-based drug called ferumoxytol to the standard treatment for glioblastoma brain tumors is safe and helpful. The study involves about 17 adults who have just been diagnosed. The main goal is t…

This early-stage study is testing whether the drug niraparib can effectively reach brain tumors and slow their growth. It involves 42 adults with newly diagnosed glioblastoma or a specific type of recurrent brain cancer. The trial first checks if the drug gets into the tumor duri…

This early-stage study is testing whether adding an experimental drug called S-Gboxin to standard brain cancer treatment helps control aggressive tumors like glioblastoma. It will involve about 10 patients with these difficult-to-treat cancers. Researchers will monitor how patien…

This early-stage trial is testing whether combining two immunotherapy drugs with a precise, high-dose radiation treatment is safe and might help control recurrent glioblastoma, a very aggressive brain cancer. The study involves about 16 patients whose cancer has returned after in…

This early-stage study is testing the safety of a new, one-time gene therapy called Temferon for patients with a specific, hard-to-treat form of glioblastoma brain cancer. Doctors take a patient's own blood stem cells, genetically modify them to produce a cancer-fighting protein,…

This is an early-stage safety study testing a new type of personalized cell therapy for aggressive brain tumors in adults and children. Doctors take a patient's own immune cells, modify them in a lab to better target and attack cancer cells that have a specific marker called CD70…

This study is testing a cancer vaccine called SurVaxM in children and young adults with aggressive brain tumors that have come back or progressed. The vaccine is designed to teach the body's immune system to find and destroy cancer cells that carry a specific protein called survi…

This early-stage study is testing a new drug called ST101 in patients with advanced solid tumors that cannot be surgically removed and have spread. The trial aims to find a safe and effective dose for cancers including glioblastoma, melanoma, breast cancer, and prostate cancer in…

This study is testing whether aiming higher doses of radiation at a specific area of the brain, called the subventricular zone, can help control glioblastoma tumors for longer than standard radiation. The trial involves 60 adults with newly diagnosed glioblastoma who will receive…

This trial aimed to test an experimental virus therapy called G207 for children whose aggressive brain tumors had returned. The virus is designed to infect and kill cancer cells while sparing healthy ones. Doctors planned to inject the virus directly into the tumor and follow it …

This is a first-in-human safety study testing a genetically engineered virus, rQNestin34.5v.2, as a potential treatment for recurrent malignant brain tumors (gliomas). The virus is designed to infect and kill only cancer cells while sparing healthy brain tissue. The main goals ar…

This study is testing whether adding high-dose vitamin C given through an IV can improve outcomes for adults with a serious type of brain cancer called glioblastoma. All 90 participants will receive the vitamin C infusions along with the standard treatment of radiation and chemot…

This study is testing if a new drug called NanO2 can help standard radiation and chemotherapy work better for people newly diagnosed with glioblastoma, a fast-growing brain tumor. The idea is that NanO2 delivers extra oxygen to the tumor, which may make radiation therapy more eff…

This program provided gallium maltolate (GaM) capsules to adults with glioblastoma that had returned or stopped responding to standard treatments. Patients took one capsule daily by mouth at home for 28-day cycles. The goal was to offer a potential treatment option when no other …

This early-stage trial is testing a new drug called AZD1390 in combination with standard radiation therapy for adults with aggressive brain tumors (grade 4 glioma or glioblastoma). The study first checks if the drug successfully reaches the tumor tissue. Patients whose tumors sho…

This study tested an experimental drug called acalabrutinib (ACP-196) in adults whose aggressive brain cancer (glioblastoma) had returned after one or two prior treatments. The goal was to see if the drug could shrink tumors and was safe for these patients. It was an early-stage …

This early-stage trial is testing whether giving immunotherapy drugs before surgery helps the body's immune system fight recurrent glioblastoma, a fast-growing brain cancer. About 63 participants will receive either one drug, a combination of two drugs, or a placebo before their …