Can a pill reach brain tumors? new trial tests ribociclib before surgery

NCT ID NCT02933736

Ongoing Disease control Sponsor: Nader Sanai Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial tests whether the drug ribociclib can reach brain tumors in people with recurrent high-grade glioma or meningioma. About 48 participants take the drug before their scheduled tumor-removal surgery. The goal is to measure how much drug gets into the tumor and surrounding brain tissue, not to treat the disease directly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ribociclib (a targeted cancer drug taken as a pill)
What this could lead to: If it works, this could show that ribociclib reaches brain tumors effectively, pointing toward a new treatment option for these hard-to-treat cancers.
What could go wrong: This is a very early, small study (48 people) focused on drug penetration, not on curing the disease. The drug may not work well enough or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma glioma susceptibility 1 malignant glioma meningioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA MULTIFORME MENINGIOMA

Contacts and locations

Locations

Barrow Brain and Spine

Phoenix, Arizona, 85013, United States

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