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Brain cancer breakthrough? trial adds radiation during surgery to fight glioblastoma

NCT ID NCT02685605

Ongoing Disease control Sponsor: Universitätsmedizin Mannheim Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether giving a dose of radiation directly to the tumor site during surgery (intraoperative radiotherapy) can help people with a newly diagnosed aggressive brain cancer called glioblastoma live longer without their cancer growing. The study involves 314 adults aged 18 to 80 who are healthy enough for surgery. The goal is to see if adding this extra radiation to the usual treatment plan improves outcomes.

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Conditions

The condition(s) this trial relates to.

glioblastoma glioma susceptibility 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA

Contacts and locations

Locations

  • Barrow Neurological Institute (SJHMC)

    Phoenix, Arizona, 85013, United States

  • Beijing Tian Tan Hospital, Capital Medical University

    Beijing, 100050, China

  • Catalan Institute of Oncology (ICO)

    Barcelona, 08908, Spain

  • Charité - Universitätsmedizin

    Berlin, 13353, Germany

  • Gangnam Severance Hospital, Yonsei University College of Medicine

    Seoul, 06273, South Korea

  • Helios University Hospital Wuppertal

    Wuppertal, 42283, Germany

  • Hospital Alemão Oswaldo Cruz

    São Paulo, 01323-020, Brazil

  • Hospital Reina Sofia

    Córdoba, Spain

  • Klinikum Stuttgart

    Stuttgart, 70174, Germany

  • Lenox Hill Hospital, Hofstra Northwell School of Medicine

    New York, New York, 10028, United States

  • Long Island Jewish Medical Center, North Shore University Hospital

    Lake Success, New York, 11042, United States

  • Montreal Neurological Institute and Hospital

    Montreal, Quebec, H3A 2B4, Canada

  • St. Georg Hospital

    Leipzig, Germany

  • Stritch School of Medicine Loyola University

    Maywood, Illinois, 60153, United States

  • Technical University of Munich (TUM), Department of Radiation Oncology

    Munich, 81675, Germany

  • The London Clinic

    London, W1G 6BW, United Kingdom

  • University Hospital Augsburg

    Augsburg, 86156, Germany

  • University Hospital Mannheim

    Mannheim, 68167, Germany

  • West Virginia University

    Morgantown, West Virginia, 26506-9260, United States

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