Experimental combo targets Hard-to-Treat brain cancers
NCT ID NCT00268385
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage study tested the safety and best dose of vorinostat when given with the chemotherapy drug temozolomide in 83 adults with aggressive brain tumors called malignant gliomas. The goal was to see if adding vorinostat could make the tumor cells more sensitive to chemotherapy, potentially improving treatment. The study focused on finding the safest dose and monitoring side effects, not on curing the disease.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322, United States
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Moffitt Cancer Center
Tampa, Florida, 33612, United States
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National Cancer Institute Neuro-Oncology Branch
Bethesda, Maryland, 20892, United States
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UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095, United States
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UCSF Medical Center-Mount Zion
San Francisco, California, 94115, United States
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UT MD Anderson Cancer Center
Houston, Texas, 77030, United States
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University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233, United States
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University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, 19104, United States
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University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States