Custom-Made vaccine targets deadly brain cancer in tiny pilot trial
NCT ID NCT04015700
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tested a personalized DNA vaccine designed to train the immune system to attack glioblastoma, a fast-growing brain cancer. Nine patients with a specific type of glioblastoma (unmethylated MGMT) received the vaccine along with an immune booster. The main goals were to see if the vaccine was safe, could be made quickly enough, and triggered an immune response. Results are still being analyzed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Personalized neoantigen DNA vaccine (GNOS-PV01) plus IL-12 plasmid, delivered via electroporation device
- What this could lead to
- If successful, this could point toward a personalized immune-based treatment for glioblastoma, potentially extending survival.
- What could go wrong
- This is a very early (Phase 1) pilot study with only 9 participants. The vaccine may not trigger a strong enough immune response, and side effects could be significant. Many early cancer vaccines fail to show benefit in larger trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Washington University School of Medicine
St Louis, Missouri, 63110, United States
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