Engineered immune cells delivered directly to the brain show promise for kids with deadly tumors

This early-stage trial tests a new treatment for children and young adults up to age 21 with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a protein called B7-H3 found on tumor cells. These cells are delivered directly into the fluid around the brain through a small tube. The main goal is to find the safest dose and see if the treatment can shrink tumors.