St. Jude Children's Research Hospital

This early-stage study tests whether adding a new drug called revumenib to two standard chemotherapy drugs is safe for children and young adults whose acute myeloid leukemia (AML) has not responded to treatment or has returned. The study involves 24 participants and aims to find …

This study tests a special cell therapy (CAR T) for children and young adults whose leukemia has not responded to standard treatments or has returned. About 25 participants will receive modified immune cells designed to attack cancer cells, along with chemotherapy to prepare the …

This early-phase study tests a new type of immune cell therapy (CAR T cells) that targets two proteins, CD19 and CD22, on leukemia cells. It is for children and young adults up to age 21 whose leukemia has returned or not responded to standard treatments. The main goal is to find…

This study tests a new treatment for children and young adults up to age 21 with sarcomas that have come back or not responded to standard therapy. It combines a special type of immune cell (B7-H3-CAR T cells) with targeted radiation to see if it is safe and can shrink tumors. Ab…

This early-phase study tests a personalized cell therapy for children and young adults up to age 21 with solid tumors that have returned or not responded to standard care. The therapy uses the patient's own immune T cells, which are genetically modified to recognize and attack a …

This study is for children and young adults (ages 1 to 30) whose solid tumors have come back or not fully responded to treatment. It tests two different drug pairs: Onivyde with talazoparib, or Onivyde with temozolomide. Both combos aim to damage cancer cell DNA so the cells die.…

This early-phase study tests the safety of a one-time gene-edited stem cell treatment for people with severe sickle cell disease. The therapy uses CRISPR technology to boost fetal hemoglobin, which may reduce painful crises and other complications. Up to 25 participants aged 18 t…

This study is for children and young adults (up to age 30) with a rare type of soft tissue cancer called non-rhabdomyosarcoma. The goal is to see if adding the targeted drug pazopanib (and another drug, selinexor, for high-risk patients) to standard chemotherapy and radiation can…

This study tests a drug called mirdametinib in children, teens, and young adults with low-grade glioma, a type of brain tumor. The drug is designed to reach the brain and block signals that help tumors grow. The goal is to find the best dose and see if it can shrink or stabilize …

This early-stage trial tests a new treatment for children and young adults up to age 21 with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack a pro…

This study tests whether adding dasatinib or venetoclax to standard chemotherapy can help more children with T-cell acute lymphoblastic leukemia or lymphoma achieve a deep remission. About 100 children and young adults aged 1 to 18 will receive one of these targeted drugs alongsi…

This early-phase trial tests a new treatment called CD123-CAR T cells for children and young adults (up to age 21) with certain types of leukemia or related blood cancers that have come back or not responded to standard therapy. The treatment involves collecting the patient's own…

This study tests a new way to do a stem cell transplant for children with a hard-to-treat type of leukemia (ALL). It uses special immune cells (CAR T cells) from a partially matched family donor to try to kill any remaining cancer cells after the transplant. The goal is to see if…

This study tests whether giving young children (under 5) with medulloblastoma a treatment plan based on their tumor's genetic makeup can improve survival and reduce long-term side effects. About 130 children will receive different combinations of chemotherapy and, in some cases, …

This early-stage study is testing a new type of immune cell therapy (CAR T-cells) for children and young adults up to age 21 whose leukemia has returned or not responded to standard treatments. The therapy uses donor immune cells that are specially trained to find and attack canc…

This study tests a drug called CM4620 in children and young adults who develop pancreatitis (inflammation of the pancreas) from a chemotherapy drug called asparaginase. The goal is to see if CM4620 is safe and can prevent severe complications like pancreatic cysts or tissue death…

This study tests whether giving two targeted immunotherapy drugs (inotuzumab and blinatumomab) together at the start of treatment can eliminate leukemia cells more effectively than standard chemotherapy in children and young adults (ages 1-18) with newly diagnosed B-cell acute ly…

This study tests if a long-acting antibiotic called dalbavancin can prevent serious bloodstream infections in children and young adults with high-risk leukemia who are receiving strong chemotherapy. About 29 participants will receive the drug every 28 days. The goal is to see if …

This early-phase study tests whether fecal microbiota transplantation (FMT) is safe and feasible for children under 22 who have ongoing gut issues after a stem cell transplant. The treatment aims to restore healthy gut bacteria to ease symptoms like diarrhea and pain. Only 10 par…

This study tests whether specially selected immune cells from a donor can safely treat cytomegalovirus (CMV) and adenovirus (ADV) infections in children who have had a stem cell transplant. About 42 participants will receive these virus-fighting cells and be monitored for viral l…

This study tests a new way to give proton radiation to children with low-grade glioma, a common brain tumor. The goal is to avoid the hippocampus, a brain area key for memory, to reduce long-term memory loss. About 74 children will receive this targeted radiation, and researchers…

This study tests a drug called entrectinib for children under 3 with certain types of brain tumors. The drug targets specific gene changes (NTRK or ROS1) to shrink tumors and delay their growth. About 52 children will take the pill, and doctors will monitor how well it works and …

This early-stage trial tests a new treatment for children and young adults (up to age 21) with blood cancers like leukemia or lymphoma that have returned or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recogn…

This study tests the safety and effectiveness of combining four drugs (cyclophosphamide, sorafenib, bevacizumab, and atezolizumab) in children and young adults up to age 30 with solid tumors that have come back or not responded to treatment. The trial has two parts: first, findin…

This early-stage study tests a new way to do stem cell transplants for children and young adults with hard-to-treat blood cancers. The approach uses special immune cells from a half-matched donor to help the body accept the transplant and fight cancer, while trying to lower the r…

This study tests whether a precise type of radiation called proton beam therapy can treat Wilms tumor while causing less damage to healthy tissue. About 260 children with newly diagnosed Wilms tumor who need abdominal radiation will take part. The goal is to see if this approach …

This study tests whether adding an experimental immune-boosting drug (N-803) to standard chemo-immunotherapy can help children and young adults with neuroblastoma that has come back or not responded to treatment. About 54 participants will receive the combination to see if it is …

This study tests whether a special type of immune cell, called B7-H3-CAR T cell, can help prevent bone cancer from returning in children with high-risk osteosarcoma. Participants receive the cells after completing standard chemotherapy. The goal is to see if this approach improve…

This study tests a weight loss program for adult survivors of childhood acute lymphoblastic leukemia (ALL) who are overweight or have obesity. Participants receive a weekly injection of tirzepatide plus remote, supervised resistance exercise three times a week for 28 weeks. The g…

This study looks at whether a wearable device and a questionnaire can spot autonomic dysfunction—a condition affecting automatic body functions like heart rate—in survivors of childhood leukemia and lymphoma. Researchers will compare these remote methods to standard in-person tes…

This program offers a special PET scan using a radioactive tracer called methionine to help doctors better see and manage central nervous system (brain, spine) and head/neck tumors in children and young adults. The scan provides extra information that can guide treatment decision…

This study tests a special cooling cap (Paxman scalp cooling device) to see if it can safely prevent hair loss in 40 children and young adults receiving chemotherapy for non-cancerous conditions or solid tumors. The cap is worn during treatment to cool the scalp. The main goals a…

This study tests if a specially designed mobile app (WebMAP Onc) can help reduce chronic pain and improve daily functioning in adolescent survivors of childhood cancer. Researchers will compare the app to standard pain education in 228 participants (teens and their caregivers) ac…

This study tests whether virtual reality can make cognitive training more engaging and effective for children aged 8-22 who are receiving radiation for brain tumors. About 45 participants will be randomly assigned to do brain exercises on an iPad or in virtual reality. Researcher…

This study explores whether a creative writing program can improve well-being for teens and young adults (ages 15-25) with cancer. Researchers at St. Jude Children's Research Hospital want to see if participants find the writing exercise valuable and easy to do. The goal is to un…

This study tests whether children with sickle cell disease can safely take a daily stimulant medication (methylphenidate) for 4 weeks to improve attention, thinking, and school performance. About 72 children ages 8 to 17 will participate. The goal is to see if the treatment is pr…

This study looks at whether a 12-week high intensity interval training (HIIT) program is doable for young people who finished treatment for Hodgkin lymphoma within the last two years. Researchers want to see if it can improve heart and lung fitness, body strength, and overall hea…

This study tests a small, non-invasive earbud that gently stimulates a nerve in the ear to help adult survivors of childhood leukemia who have trouble sleeping. About 40 participants will use either the active device or an inactive one nightly for up to 8 weeks. Researchers will …

This study looks at whether using virtual reality (VR) can help reduce pain in children and young adults with sickle cell disease who are having a painful crisis. About 76 participants, ages 6 to 25, will either get standard pain treatment alone or standard treatment plus VR. Res…

This study looks at why some survivors of childhood leukemia have weak muscles. Researchers will use MRI scans, ultrasound, and small muscle samples to compare survivors with healthy volunteers. The goal is to learn more about how cancer treatment affects muscles over time. No ne…

This study tests a school readiness program for children aged 3.5 to 6.5 years with sickle cell disease. The program is designed to help prepare them for school. Researchers will check if the program is easy to use and if it helps improve school readiness skills compared to usual…

This study watches how spinal muscular atrophy (SMA) drugs work on muscles and nerves in 24 children and teens (ages 5-20) with SMA types 2 and 3. Researchers use MRI scans, strength tests, and blood samples to track changes over 12 months. The goal is to better understand how tr…

This study looks at why the heart gets damaged in people with sickle cell disease. Researchers will use special PET scans to measure blood flow to the heart during rest and stress. They will compare results from 40 young adults—some with sickle cell disease and some without—to se…

This study looks at how sleep problems affect memory and thinking in teens (ages 12-18) with sickle cell disease. Participants will use a home sleep monitor and complete thinking tests during a clinic visit. The goal is to understand the link between nighttime oxygen levels and b…

This study looks at whether girls with sickle cell disease have lower levels of a hormone called AMH, which is a marker of egg supply in the ovaries. Researchers will compare AMH levels in girls with sickle cell disease to healthy girls of the same age and stage of puberty. The g…

This study looks at how a child's genes influence the way their body processes medicines. Researchers will analyze DNA from up to 8,800 participants, including children with serious illnesses, their family members, and healthy volunteers. The goal is to understand why some childr…

This study looks at the long-term health and quality of life of children, teens, and young adults who received CAR T-cell therapy for B-cell acute lymphoblastic leukemia (B-ALL) at least two years ago. Researchers want to see if it's possible to regularly check for late side effe…

This study aims to understand how hope is experienced and expressed by children (ages 12-25) with relapsed or hard-to-treat cancer and their families during phase 1/2 clinical trials. Researchers will use photos and interviews to capture their stories, then work with families and…

This study follows up to 1,000 people who received genetically modified cell therapy for blood cancers at St. Jude. The goal is to track any long-term health effects over 15 years. No new treatment is given—just regular check-ins to ensure safety.

This study collects and stores samples of tissue and body fluids from patients, their relatives, and healthy volunteers at St. Jude Children's Research Hospital. The goal is to create a large, organized bank of samples and related health information that researchers can use to be…

This study is a worldwide registry that collects medical information, family cancer history, and tumor samples from children and teens with adrenocortical tumors. Researchers aim to better understand the disease, how it is treated, and the role of genes like TP53. Participants in…

This study tests a new substance called [18F]-fluoromannitol, used in PET scans, to see if it is safe and how it spreads in the body. Ten healthy adults aged 18-75 will receive the tracer and be monitored for side effects. The goal is to gather safety data so this tracer can late…

This research study aims to discover new genes that may cause cancer to run in families. It will enroll up to 1,500 people from families where multiple members have had childhood cancers or related conditions. Participants provide blood samples and health information, which are s…

This study looks at how serious walking problems are for children with bone or soft tissue cancer who have had orthopedic surgery. Researchers will use 3D cameras and sensors to track their movement for up to 5 years and compare it to healthy kids of the same age. The goal is to …

This study tests whether a communication skills training program designed for rehabilitation professionals (like physical and speech therapists) is practical and helpful. About 25 staff at St. Jude will take part, and researchers will measure how well the training works and how i…

This study follows 10,000 childhood cancer survivors over their lifetime to understand long-term health effects from cancer treatments. Participants must be at least five years past diagnosis. Researchers will track medical, social, and behavioral factors to improve screening and…

This study follows 100 children and young adults who received CAR T cell therapy to understand short- and long-term side effects like infections, slow blood cell recovery, and nerve problems. Researchers will check participants at 3, 6, 12, and 24 months after treatment. The goal…

This early-stage study tests whether the drug motixafortide is safe for people with sickle cell disease and whether it can increase the number of stem cells that can be collected from their blood. These stem cells could be used in future gene therapies or transplants. The study i…

This study collects information directly from people (ages 8 and older) with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) about their symptoms and quality of life. Participants will fill out surveys over time to help researchers understand how the disease and its treat…

This study follows about 50,000 people who survived childhood cancer (diagnosed before age 21) to see how their health changes over time. Researchers compare them with 10,000 siblings to learn about late effects from treatments like radiation and chemotherapy. The goal is to impr…

This study looks at Hodgkin lymphoma survivors who had chest radiation and bleomycin treatment as children. Researchers want to understand how these treatments affect blood flow to the brain and heart-lung function during exercise. About 100 survivors and healthy volunteers will …

This study looks at sleep issues in adults who had childhood cancer, including leukemia, brain tumors, and solid tumors. Researchers will use questionnaires and sleep-monitoring devices to measure insomnia, sleep quality, and daytime sleepiness. The goal is to find out how common…

This study collects health information from up to 30,000 children and adults who have or had childhood cancer at St. Jude Children's Research Hospital. The goal is to track how well treatments work and what long-term side effects may occur. By following patients over time, resear…

This study is testing whether a green dye called ICG can help surgeons see tumors more clearly during surgery in children and teens with solid tumors. The dye is injected before surgery and makes tumor tissue glow under a special camera. The goal is to see if this technique helps…

This study aims to understand how well the seasonal flu vaccine works in children with blood cancers like leukemia. Researchers will measure the immune response in up to 150 children at St. Jude Children's Research Hospital. The goal is to see if the vaccine triggers enough prote…

This study follows 56 adolescents and young adults who have a genetic condition that raises their cancer risk. Researchers want to see if these patients find adult doctors and continue getting regular cancer screenings after they leave pediatric care at St. Jude Children's Resear…

Childhood cancer survivors who had certain treatments are at higher risk for heart problems. This study tests an online education program to encourage them to get a recommended heart screening test. Researchers will compare the program to standard care in 350 survivors to see if …

This study looks at how parents and children (ages 10-24) talk about the child's genetic risk for cancer. Researchers want to find out what helps or hinders these conversations, and how they affect the child's feelings and health choices. The goal is to improve genetic education …

This study talks to parents and teens with sickle cell disease to learn what they think about genetic research and gene therapy. Researchers will use surveys and interviews to understand concerns and expectations. The goal is to create better educational tools and build trust bet…

This study aims to learn more about the genetic and immune characteristics of several types of solid tumors in children, including neuroblastoma, osteosarcoma, and Ewing sarcoma. Researchers will collect tumor and blood samples from up to 1,000 participants to analyze genes, prot…

This study is testing a new way to help teenagers with hard-to-treat cancers, their parents, and their doctors have better conversations about what the future may hold. Researchers want to see if this approach is practical and helpful for everyone involved. About 85 people will t…

This study follows 184 people who survived medulloblastoma (a type of brain tumor) after receiving radiation therapy. Researchers want to learn about long-term health problems like memory issues, hearing loss, heart and hormone problems, and physical fitness. The goal is to find …

This study collects blood, bone marrow, and other samples from up to 1,716 people with non-cancerous blood diseases and their family members. Researchers will analyze genes to find causes of these diseases and why some people get sicker than others. The goal is to improve future …

This study follows up to 10,000 people with sickle cell disease over many years, starting in childhood and continuing into adulthood. Researchers collect health data and blood samples during regular clinic visits to learn how treatments like hydroxyurea affect long-term organ fun…

This study interviews 145 people—patients and parents of children with rare diseases like sickle cell disease—to learn what they think and want to know about gene therapy. Researchers will use these insights to create an online tool with educational content and decision aids. No …

This study looks at the reasons parents consider when deciding whether to enroll their child in a cancer clinical trial. Researchers will survey and interview 400 parents of children newly diagnosed with cancer. The goal is to understand how social factors, personal preferences, …

This study is collecting and analyzing the complete genetic information (genomes) of up to 2,500 children with cancer. The goal is to learn how gene changes cause different tumors and affect treatment outcomes. This is a non-therapeutic study, meaning it does not test a new treat…

This study interviews patients, families, healthcare providers, and researchers to learn their views on the ethical issues of small-scale, personalized treatments for rare neurological diseases. About 385 participants will share their perspectives through interviews and surveys. …

This early-phase study tests if a safe dye called Indocyanine Green (ICG) can help surgeons find cancer that has spread to lymph nodes in children with solid tumors in the belly. About 25 children under 21 with Wilms tumor or a type of muscle cancer will get the dye during surger…

This study looks at how young adult survivors of childhood leukemia feel about exercise, using a special computer test and interviews. About 125 survivors who are not very active will take part. The goal is to see if this test can help understand their emotions and thoughts about…

This study enrolls children and teens (ages 1-18) newly diagnosed with certain types of leukemia or lymphoma. The main goal is to gather enough information from their tumor samples to figure out their risk of the cancer coming back, so they can be placed into the right treatment …

This study looks at the genetic makeup of skin growths (including melanoma) in children and teens under 19. Researchers will analyze tissue samples already stored or newly collected to learn more about these rare childhood cancers. No new treatments are given—the goal is simply t…

This study collects bone marrow samples that would otherwise be thrown away during surgery. Researchers will use them to develop better gene therapies and treatments for sickle cell disease and thalassemia. Up to 50 children and adults with or without these blood disorders will p…