St. Jude Children's Research Hospital

This study tests whether specially selected immune cells from a donor can safely treat cytomegalovirus (CMV) and adenovirus infections in children who have had a stem cell transplant. About 42 participants will receive these virus-fighting cells and be monitored for viral load re…

This early-phase study tests a new treatment called CD70-CAR T-cells for children and young adults (up to age 21) with blood cancers like leukemia, lymphoma, or MDS that have returned or not responded to standard therapy. The treatment involves taking the patient's own immune cel…

This study tests a combination of four drugs (cyclophosphamide, sorafenib, bevacizumab, and atezolizumab) in children and young adults up to age 30 whose solid tumors have come back or not responded to standard therapy. The goal is to find safe doses and see if the combination ca…

This study tests a new treatment for children and young adults (up to age 21) with a type of leukemia (CD19-positive) that has returned or not responded to standard therapy. The treatment uses specially engineered immune cells from a family donor to attack the cancer. The main go…

This early-phase study tests a new treatment for children and young adults up to age 21 with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack tumor…

This study tests whether customizing treatment based on the tumor's genetic makeup can help children under 5 with medulloblastoma live longer with fewer side effects. About 130 children will receive different combinations of chemotherapy and, if needed, radiation. The goal is to …

This study tests a monthly antibiotic called dalbavancin to prevent serious bloodstream infections in children and young adults with high-risk leukemia who are receiving strong chemotherapy. About 29 participants will receive the drug every 28 days for up to 12 weeks. The goal is…

This study looks at whether a wearable device and a questionnaire can spot autonomic dysfunction (a nerve problem affecting heart rate and other body functions) in survivors of childhood leukemia and lymphoma. The goal is to see if these remote methods work as well as standard in…

This study tests a new way to give proton radiation to children with low-grade glioma, a common brain tumor. The goal is to avoid the hippocampus, a brain area key for memory, to reduce long-term memory problems. About 74 children will receive this targeted radiation, and researc…

This study tests whether a mobile app (WebMAP Onc) that teaches coping skills can reduce chronic pain and improve daily life in teens who survived childhood cancer. About 228 participants (teens and their caregivers) will be randomly assigned to use the app or receive standard pa…

This study tests whether using virtual reality (VR) alongside standard pain medicine can better reduce pain in children and young adults with sickle cell disease during a painful crisis. About 76 participants aged 6 to 25 will be randomly assigned to receive either standard care …

This study tests whether children with sickle cell disease can safely take a daily stimulant medication (methylphenidate) for four weeks to help with attention, thinking, and schoolwork. Researchers will track side effects, how well families stick with the treatment, and any impr…

This study is for children with blood cancer who are getting the seasonal flu vaccine. Researchers want to see how their immune systems respond to the vaccine and how long protection lasts. The goal is to better understand if the flu shot works well in these children and helps pr…

This study tests whether a communication skills training program helps rehabilitation professionals (like physical and speech therapists) feel more comfortable and confident when having difficult conversations with families of children with serious illnesses. About 25 professiona…

This study is testing a school readiness program for children aged 3.5 to 6.5 years who have sickle cell disease. The goal is to see if the program is practical and helpful for families. Researchers will compare children in the program to those receiving usual care to measure ear…

This study follows about 50,000 people who survived childhood cancer (diagnosed before age 21) to learn about their long-term health. Researchers will compare them with 10,000 siblings to see how treatments like radiation, chemotherapy, and surgery affect health years later. The …

This study talks to parents and teens with sickle cell disease to learn what they think about genetic research and gene therapy. Researchers will use surveys and interviews to measure knowledge, trust, and concerns. The goal is to create a web tool that helps families and doctors…

This study is creating a worldwide registry to collect medical information, family history, and tumor samples from children and teens with adrenocortical tumors. Researchers hope to better understand how these rare tumors develop, what treatments work best, and what role genetics…

This study tests a new way to help teens with serious cancer, their parents, and doctors have better conversations about what the future may hold. Researchers want to see if this personalized approach is practical and helpful for everyone involved. The goal is to improve how fami…

This study follows 100 children and young adults who received CAR T-cell therapy to learn about side effects like infections, slow blood cell recovery, and nerve problems. Researchers want to understand how often these issues happen and how long they last. The goal is to improve …

This study enrolls children aged 1 to 18 with newly diagnosed acute lymphoblastic leukemia, lymphoblastic lymphoma, or mixed phenotype acute leukemia. The goal is to collect enough information about each child's cancer to determine their risk group and which treatment study they …

This study collects bone marrow that is normally thrown away during orthopedic surgery. Researchers will use these samples to learn how to better perform gene therapy and gene editing for blood disorders like sickle cell disease and thalassemia. Up to 50 participants of any age w…

This study talks to patients and parents of children with sickle cell disease to learn what they think and want to know about gene therapy. Researchers will use these insights to create an online tool that helps families make informed choices. No treatment is given—this is purely…

This study tests a new substance called [18F]-fluoromannitol, used in PET scans, to see if it is safe and how it spreads in the body. Ten healthy adults aged 18-75 will receive the tracer and be monitored for side effects. The goal is to gather safety data so this tracer can late…

This study collects information directly from patients (ages 8 and up) with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) about their symptoms and quality of life. Researchers will use surveys to track how patients feel over time and during treatment. The goal is to bui…

This study looks at whether sickle cell disease affects the ovaries of girls aged 10 to 18. Researchers will measure a hormone called AMH to compare ovarian health between girls with sickle cell and healthy girls of the same age and stage of puberty. The goal is to understand how…

This study will follow up to 10,000 people with sickle cell disease over many years, collecting health data and blood samples at regular clinic visits. The goal is to understand how the disease damages organs over time and how treatments like hydroxyurea affect long-term health. …

This study interviews patients, families, healthcare providers, and researchers to learn their views on the ethical challenges of small-scale, personalized treatments for rare neurological diseases. About 385 participants will share their opinions through interviews and surveys. …

This study looks at whether it's possible to regularly check for long-term health problems in people who survived high-risk neuroblastoma. Researchers will invite 45 survivors treated at St. Jude at least 2 years ago to undergo a series of health tests. The goal is to see if enou…