Engineered immune cells take on tough leukemia in kids
NCT ID NCT06847269
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a personalized cell therapy for children and young adults with a type of leukemia that has come back or not responded to standard treatment. Doctors collect the patient's own immune cells, modify them to recognize and attack cancer cells, and give them back after chemotherapy. The goal is to find the best chemotherapy dose and see how long the modified cells last in the body.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CD19-CAR T cells (immune cells modified to target cancer) plus fludarabine and cyclophosphamide chemotherapy
- What this could lead to
- If successful, this could improve how we use CAR T cell therapy for hard-to-treat leukemia in young patients, potentially leading to better outcomes.
- What could go wrong
- This is a small, early-phase study (25 participants) focused on drug dosing and safety, not yet proven to work. Side effects from chemotherapy and CAR T cells can be serious.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
-
Contact
Email: •••••@•••••
Locations
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St. Jude Children's Research Hospital
RECRUITINGMemphis, Tennessee, 38105, United States
Contact Email: •••••@•••••
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