St. Jude Children's Research Hospital

This study tests a new nasal vaccine to prevent croup, a common childhood illness that can cause breathing problems. The vaccine uses a harmless virus (Sendai virus) that is similar to the croup virus. Researchers want to see if it is safe and helps children build immunity. About…

This study tests a new treatment approach for patients with Ewing sarcoma or desmoplastic small round cell tumors, especially those at high risk of the cancer coming back. Participants are split into two groups: standard-risk patients get standard therapy, while high-risk patient…

This study tests a drug called alisertib in children and young adults under 22 with rare, aggressive tumors of the brain (AT/RT) or kidney (MRT). For those whose cancer has returned, alisertib is given alone. For newly diagnosed patients, it is combined with chemotherapy and some…

This study looks at whether a newer type of proton radiation can better treat craniopharyngioma, a rare brain tumor near the pituitary gland. It involves up to 160 children and young adults whose tumor was not fully removed. The goal is to see if this treatment controls the tumor…

This study tests a new way to do stem cell transplants for children and young adults with high-risk blood cancers like leukemia and lymphoma. Donor cells are treated in a lab to remove certain T cells that can cause a serious side effect called graft-versus-host disease. After th…

This study tests whether adding two adult cancer drugs, bortezomib and vorinostat, to standard chemotherapy can better treat infants with acute lymphoblastic leukemia (ALL). About 50 infants under one year old with newly diagnosed ALL will receive the combination. The goal is to …

This study tests an investigational drug called CPX-351 in 25 children and young adults (ages 1 to 21) who have developed a secondary blood cancer after previous cancer treatment. The goal is to see if the drug can put the cancer into remission so they can receive a stem cell tra…

This study tests a new treatment called SJCAR19 for children and young adults up to age 21 whose leukemia has come back or not responded to standard therapy. The treatment uses the patient's own immune cells, which are modified in a lab to better find and kill cancer cells. The s…

This study tests a treatment plan for young children with certain brain tumors. The approach uses chemotherapy first to delay radiation, giving the brain more time to develop. Then, radiation is carefully aimed only at the tumor area to reduce learning and thinking problems. The …

This study tests a new approach to help childhood cancer survivors who struggle with memory, attention, and thinking speed. Participants use a special light device at home (called transcranial photobiomodulation) while doing computer-based brain training. The goal is to see if th…

This study looks at how cancer affects the social experiences of teenagers and young adults, both during and after treatment. Researchers will interview about 121 participants aged 15-22 to understand their friendships, feelings of loneliness, and social support needs. The goal i…

This study tests whether a heart MRI can be done safely and successfully in children with cancer who have recently had sepsis. The goal is to find hidden heart problems that may need treatment. About 7 children aged 9 to 25 will get a heart MRI within 10 days of their sepsis diag…

This pilot study looks at whether adult survivors of childhood cancer are willing to do two behavioral therapies together—exercise plus either brain training or mindfulness—for 12 weeks. The goal is to see if this combined approach is acceptable and can help with thinking problem…

This study asks 10 young adult survivors of childhood cancer (ages 18-39) to review and give feedback on exercise videos. The goal is to make the videos more relatable and useful for survivors. No treatment is tested; the study focuses on gathering opinions to improve future exer…

This study looks at how having cancer as a young child (ages 4-6) affects their social development. Many children miss normal social activities like preschool and playgrounds. Researchers will follow 119 children who finished cancer treatment 6-12 months ago to see how their soci…

This study involves 837 adult survivors of childhood cancer. Researchers are developing and testing a questionnaire that lets survivors report their own symptoms, such as pain or fatigue, to help doctors better manage long-term side effects. The goal is to create a reliable tool …

This study looks at whether a special electronic pill bottle (AdhereTech) can accurately track how often teens with sickle cell disease take their medication, hydroxyurea. About 36 teens aged 12-17 will use the bottle for two months. The goal is to see if this device gives a bett…

This study looks at whether a special PET scan using a radioactive form of methionine (an amino acid) can help doctors see tumors in children and young adults with various cancers, including brain tumors and sarcomas. About 500 participants will be scanned to see how well the met…

This study looks at whether a new DNA-based test can predict bloodstream infections in children and teens with cancer who are at high risk. Current methods often detect infections too late, leading to serious illness or death. The researchers will compare the DNA test results wit…

This study follows over 1,500 young adult survivors of childhood cancers like leukemia, brain tumors, and Hodgkin lymphoma to see how frailty—a measure of physical weakness and vulnerability—changes over five years. Researchers want to find out if frailty can predict future chron…