St. Jude Children's Research Hospital

This study tests a new nasal spray vaccine to prevent croup, a common childhood illness that can cause breathing trouble. The vaccine uses a harmless virus (Sendai virus) that is similar to the croup virus. About 54 children ages 1 to 5 will receive the vaccine to see if it is sa…

This early-stage study tests two drugs, selinexor and venetoclax, given together with standard chemotherapy for children and young adults whose acute myeloid leukemia (AML) has returned or not responded to treatment. The main goal is to find the safest dose and see how well the c…

This study tests a personalized approach for children aged 1-18 with newly diagnosed acute lymphoblastic leukemia or lymphoma. Using genetic information from each child's cancer, doctors add targeted drugs or immunotherapy to standard chemotherapy to improve cure rates and reduce…

This study tests two drugs, venetoclax and navitoclax, combined with other treatments for children whose acute lymphoblastic leukemia has returned or not responded to standard therapy. The goal is to see if this combination can clear the leukemia from the bone marrow more effecti…

This study tests a personalized treatment plan for children with a rare muscle cancer called rhabdomyosarcoma. Depending on their risk level, patients receive a combination of proton beam radiation, surgery, and chemotherapy, with some getting extra maintenance therapy. The goal …

This study tests a new treatment called SJCAR19 for children and young adults up to age 21 whose acute lymphoblastic leukemia (ALL) has come back or not responded to standard therapy. The treatment involves collecting a patient's own immune cells, engineering them in a lab to bet…

This study tests a new treatment for children and teens with high-risk Hodgkin lymphoma. It combines the targeted drug Adcetris with standard chemotherapy and, if needed, radiation. The goal is to see if this approach can shrink tumors faster and reduce the need for radiation the…

This study tests a treatment plan for children under 3 with certain brain tumors. It uses chemotherapy first to delay radiation, giving the brain more time to develop. Then, only the tumor area gets targeted radiation to reduce learning and thinking problems. The goal is to impro…

This study tests a gene transfer method for infants with X-linked severe combined immunodeficiency (SCID-X1), a genetic disorder that leaves babies without a working immune system. The approach uses a lentiviral vector to insert a normal copy of the faulty gene into the child's o…

This study tests a drug called alisertib in children and young adults (under 22) with rare, aggressive tumors called atypical teratoid rhabdoid tumors (AT/RT) in the brain or malignant rhabdoid tumors (MRT) elsewhere in the body. For patients whose tumor has come back or not resp…

This study tests whether surgery followed by a second course of radiation can help children and young adults (ages 1-21) whose ependymoma has returned after initial treatment. The combined radiation dose is higher than standard. Researchers will track how long the tumor stays und…

This study tests whether adding the drug venetoclax to standard chemotherapy is safe and effective for children and young adults (up to age 22) with newly diagnosed acute myeloid leukemia (AML). The main goals are to see if the combination is tolerable and if it can clear tiny am…

This study tests a combination of three drugs (ruxolitinib, dexamethasone, and etoposide) for children and young adults with hemophagocytic lymphohistiocytosis (HLH), a rare condition where the immune system attacks the body. The treatment is adjusted based on how well the patien…

This study tests a precise radiation technique called image-guided radiotherapy (IGRT) for children and young adults with bone or soft tissue tumors. By using CT, MRI, and PET scans to pinpoint the tumor, doctors aim to deliver radiation more accurately and reduce damage to healt…

This study tested a combination of two drugs, temozolomide and peginterferon, in children and young adults up to age 21 with advanced or recurrent melanoma that cannot be removed by surgery. The main goal was to see how well the tumors responded to treatment and to check for side…

This study tested a shorter course of chemotherapy (Stanford V) with or without low-dose radiation in 88 children and young adults with favorable Hodgkin lymphoma. The goal was to see if this approach could improve the number of patients whose cancer completely disappears while r…

This study is testing an investigational drug called CPX-351 in 25 people under age 22 who have secondary myeloid neoplasms (a type of blood cancer that develops after previous cancer treatment). The goal is to see if the drug can safely put the cancer into remission before a ste…

This study tests a newer form of proton therapy for people with craniopharyngioma, a rare brain tumor near the pituitary gland. The goal is to see if this precise radiation can control the tumor and cause fewer side effects than older radiation methods. The trial includes childre…

This study tests whether adding two adult cancer drugs, bortezomib and vorinostat, to standard chemotherapy is safe and effective for infants under 1 year old with newly diagnosed acute lymphoblastic leukemia. The goal is to reduce leukemia cells and improve survival, while caref…

This study tests a personalized approach to treat medulloblastoma, a common childhood brain tumor. About 660 participants receive surgery, radiation, and chemotherapy tailored to their tumor's molecular type and risk level. The goal is to see if lower doses of radiation and chemo…

This study looks at a new way to treat craniopharyngioma, a rare brain tumor, in children and young adults up to age 21. Instead of removing the whole tumor, doctors do a smaller surgery and then use precise proton radiation to target any remaining tumor cells. The goal is to kee…

This study tests a new way to treat children and young adults with high-risk blood cancers like leukemia and lymphoma. Doctors take blood cells from a family donor, remove certain T cells that can cause a harmful immune reaction, and then transplant the modified cells. The goal i…

This study tests whether giving a drug that changes how DNA is read (called a DNA methyltransferase inhibitor) before standard chemotherapy can help children with newly diagnosed acute myeloid leukemia. About 206 participants will receive either azacitidine or decitabine for five…

This study tests whether giving different chemotherapy combinations based on a patient's risk level (low, intermediate, or high) can improve outcomes for children and young adults with Hodgkin lymphoma. About 232 participants will receive specific drug regimens, and those whose t…

This study tests two short-term drug combinations (dasatinib plus quercetin, or fisetin alone) in 110 adult survivors of childhood cancer who are frail. The goal is to see if these treatments can improve walking speed and reduce markers of cell aging in the blood. The trial is a …

This study tests a new combination of drugs (temsirolimus, temozolomide, and irinotecan) for children and young adults with high-risk Ewing sarcoma or desmoplastic small round cell tumors. Participants are split into standard-risk and high-risk groups, with high-risk patients rec…

This study tests a new radioactive tracer called 18F-DA for PET scans to see if it can find neuroblastoma and pheochromocytoma tumors more clearly than the current tracer. About 20 children and adults with known or suspected tumors will receive the tracer and be monitored for sid…

This study tests if a special PET scan using methionine, a natural amino acid, can help see tumors in children and young adults with brain or solid tumors. About 500 participants will get the scan to see how well it finds tumors and tells them apart from scar tissue. The goal is …

This study tests whether a combination of the diabetes drug metformin and a digital lifestyle program can prevent diabetes in adult survivors of childhood cancer who have prediabetes. About 96 participants will take metformin daily and complete online lessons over 24 weeks. The g…

This study aimed to see if wearing light therapy glasses could reduce depression, tiredness, and sleep problems in children and teens receiving a stem cell transplant. It planned to compare bright light to dim light over about four weeks. However, the study was withdrawn before a…

This study tests whether a special light therapy (transcranial photobiomodulation) used at home can help improve thinking and memory in adults who survived childhood leukemia or Hodgkin lymphoma. About 44 survivors will use a light device on their head while doing brain-training …

This study looks at whether adult survivors of childhood cancer are willing to take part in two activities at the same time—exercise plus either computer-based brain training or mindfulness practice—over 12 weeks. The goal is to see if this combined approach is acceptable and hel…

This study aimed to see if adult survivors of childhood cancer could use wearable devices, surveys, and lab tests at home to monitor their heart health. It was designed for survivors who had certain cancer treatments. However, the study was withdrawn before enrolling any particip…

This study aims to create and test a new questionnaire that helps adult survivors of childhood cancer report their symptoms more accurately. Researchers will work with 837 survivors to ensure the tool captures the right symptoms and is useful for doctors. The goal is to improve l…

This study looks at whether a smartwatch ECG can predict heart muscle disease (cardiomyopathy) in adult survivors of childhood cancer as well as a standard clinic ECG does. About 1,300 survivors will have both a standard 12-lead ECG and a 30-second Apple Smartwatch ECG. The goal …

This study follows 1,000 children with tumors who are receiving proton therapy as part of their regular care at St. Jude Children's Research Hospital. The goal is to track and report any serious side effects that may be linked to the radiation. No new treatments or procedures are…

This study looks at whether a special electronic pill bottle (AdhereTech) can accurately track how often teens with sickle cell disease take their medication, hydroxyurea. About 36 teens aged 12 to 17 will use the bottle for two months. Researchers will compare the bottle's data …

This study looks at how cancer treatment changes the social lives of teens and young adults aged 15 to 22. Researchers want to understand feelings of loneliness, friendships, and family connections in those currently on therapy or who have finished treatment. By interviewing abou…

This study looks at how children with cancer and their parents handle the emotional challenges of the disease. Instead of focusing only on negative effects like posttraumatic stress, researchers also explore positive changes, such as personal growth. The study compares these fami…

This study looks at how cancer and its treatment impact social development in children aged 4 to 6. About 119 children with brain or solid tumors will be assessed using parent surveys and child activities. The goal is to understand the social challenges these young survivors face…

This study looks at whether people who survived Hodgkin lymphoma after chest radiation have a higher risk of obstructive sleep apnea (a condition where breathing stops during sleep). Researchers will compare 220 survivors to similar people without cancer. The goal is to find out …

This study looks at whether a daily mindfulness app can help adults who survived childhood leukemia or lymphoma handle stress better. About 50 participants will use the app for 30 days and wear a wrist device to track stress signs. The goal is to see if this approach is practical…

This study gathers imaging data from 367 children receiving proton therapy for cancer. Researchers will analyze daily scans to understand how patient positioning and movement affect treatment accuracy. The goal is to improve future radiation therapy by identifying factors that ca…

This study looks at why many young adult survivors of childhood cancer experience early aging symptoms like fatigue and weakness, known as frailty. Researchers will follow over 1,500 survivors for five years to see how frailty changes over time and how it relates to chronic healt…

This study uses special PET scans to measure inflammation in the brain after radiation therapy in children with medulloblastoma. About 22 participants will be scanned multiple times over two years to see how inflammation changes. The goal is to better understand radiation's effec…

This study looks at whether it's possible to screen for long-term health problems in people who survived high-risk neuroblastoma. Researchers will evaluate survivors who finished treatment at least 2 years ago, using tests for heart, nerve, and other health issues. The goal is to…

This study looks at children with a type of cancer called mature B-cell lymphoma. The goal is not to test a new treatment, but to learn more about the tumor's biology and the long-term effects of current therapies. By studying genes and other factors, researchers hope to find way…

This study asks childhood cancer survivors aged 18-39 who are not very active to review exercise videos and share their thoughts. The goal is to make the videos more relatable and useful for survivors. Researchers will use interviews and a questionnaire to understand what works b…

This study looks at e-cigarette use in 500 teenage and young adult cancer survivors. Researchers want to understand why they vape and how motivated they are to quit. They will also test a mobile phone program to help them stop vaping and see what works best in a cancer clinic set…

This study looks at whether a new DNA-based test can predict bloodstream infections in children and teens with cancer who are at high risk. Current methods often detect infections too late, leading to serious illness or death. The goal is to catch infections earlier so doctors ca…

This study aimed to use wearable fitness trackers to measure heart rate and sleep patterns in adult survivors of childhood cancer. The goal was to understand how common heart-related nerve problems are in this group compared to their siblings. However, the study was withdrawn bef…

This study looks at whether data from smartphones and wearable devices can help predict future health problems in adults who survived childhood cancer. About 600 survivors will track symptoms, activity, sleep, and heart rate. The goal is to use this information to improve follow-…