Precision proton beam takes aim at childhood brain tumors

NCT ID NCT02792582

Ongoing Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a newer form of radiation called intensity-modulated proton therapy in children and young adults with craniopharyngioma, a rare brain tumor. The goal is to see if this precise radiation can better control the tumor while causing fewer side effects than older radiation methods. The trial includes 160 participants who either receive proton therapy after incomplete surgery or are simply observed after complete tumor removal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Proton therapy (a precise form of radiation)
What this could lead to: If successful, this could offer a more effective and less harmful radiation treatment for children with this rare brain tumor, potentially improving survival and quality of life.
What could go wrong: This is a phase II trial, so results are still preliminary. The therapy may not work better than standard radiation, and there are still risks of side effects from radiation exposure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

brain cancer craniopharyngioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRANIOPHARYNGIOMA

Contacts and locations

Locations

St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.