St. Jude Children's Research Hospital

This study tests a new approach to bone marrow transplant for children and young adults with sickle cell disease. Instead of a fully matched donor, it uses a half-matched family donor and a milder chemotherapy regimen to reduce side effects. The goal is to prevent graft rejection…

This study tests if shining a special light on the head (transcranial photobiomodulation) can improve thinking and brain oxygen use in children with sickle cell disease. About 60 kids aged 8-17 will be randomly assigned to get real light therapy or a placebo. The goal is to see i…

This study looks at whether taking extra CT or MRI scans during proton therapy can help doctors adjust the treatment plan for children with solid tumors or Hodgkin's lymphoma. About 100 children will get weekly or every-other-week scans to check if the tumor or healthy organs hav…

This study will follow 200 children and teens with acute lymphoblastic leukemia or lymphoma to learn more about the short- and long-term side effects of asparaginase, a key chemotherapy drug. Researchers will track how often serious side effects occur during standard treatment an…

This study looks at liver tissue from adults with hemophilia A or B who received gene therapy at least 6 months ago. Researchers want to see how the gene therapy affects liver cells over time. About 8 participants will have a liver biopsy to check for signs of damage and how many…

This study looks at 650 adult survivors of childhood cancer who are at higher risk for heart disease due to past treatments like radiation or chemotherapy. Researchers will use heart scans, blood tests, and other exams to find early signs of heart problems. The goal is to better …

This study aims to understand why childhood cancer survivors often lose muscle mass and strength earlier than normal. Researchers will use advanced scans and tests to compare muscle health in 400 survivors and 133 people without cancer. The goal is to find different types of musc…

This study looks at whether a short substance use questionnaire and supportive counseling can be easily added to regular check-ups for adult survivors of childhood cancer. About 30 survivors at St. Jude will fill out a screening form and, if needed, receive a brief counseling ses…

This early-phase study tests whether it is safe and possible to collect blood stem cells from 12 people aged 18 to 25 with bone marrow failure syndromes. Participants receive two drugs (Filgrastim and plerixafor) to move stem cells from bone marrow into the blood, where they are …