New hope for sickle cell: Half-Matched transplants aim to cut complications
NCT ID NCT07616154
First seen Jun 24, 2026 · Last updated Jul 24, 2026 · Updated 3 times
Summary
This study tests a stem cell transplant from a half-matched family donor for children and young adults with sickle cell disease. The goal is to control the disease while reducing serious side effects like graft-versus-host disease. Up to 45 participants will receive a special drug combination to help their body accept the new cells.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- stem cell transplant from a half-matched family donor
- What this could lead to
- If successful, this approach could offer a safer way to control sickle cell disease without needing a perfectly matched donor, reducing complications like graft-versus-host disease.
- What could go wrong
- This is an early phase 2 trial with only 45 participants, so results may not apply to everyone. The transplant still carries risks of rejection, infection, and side effects from chemotherapy and radiation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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St Jude Children's Research Hospital
RECRUITINGMemphis, Tennessee, 38105, United States
Contact Email: •••••@•••••
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