Weekly scans may make proton therapy safer for kids with cancer

NCT ID NCT07514819

Not yet recruiting Knowledge-focused Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This study will enroll 100 children with solid tumors or Hodgkin lymphoma who are receiving proton therapy. Researchers will take weekly or bi-weekly CT or MRI scans during treatment to check if the original radiation plan is still accurate. If tumor coverage drops by 5% or radiation to healthy organs rises by 10%, the plan will be updated. The goal is to see how often adjustments are needed and which tumors change most during treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Proton therapy with adaptive replanning
What this could lead to: If successful, this approach could make proton therapy more precise for children, potentially reducing damage to healthy tissues and improving tumor control.
What could go wrong: This is an early-stage observational study with no control group, so it cannot prove that adaptive planning improves outcomes. The findings may not apply to all tumor types or treatment centers.

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Conditions

The condition(s) this trial relates to.

bone cancer bone neoplasm childhood neoplasm Ewing sarcoma Hodgkins lymphoma osteosarcoma rhabdomyosarcoma sarcoma soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BONE TUMOR EWING SARCOMA HODGKIN LYMPHOMA OSTEOSARCOMA PEDIATRIC SOLID TUMORS RHABDOMYOSARCOMA SOFT TISSUE SARCOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

St. Jude Children's Research Hospital

Memphis, Tennessee, 38105, United States

Contact Email: •••••@•••••

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