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Engineered immune cells take aim at childhood leukemia in new trial

NCT ID NCT04318678

Recruiting now Disease control Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests a new treatment called CD123-CAR T cells for children and young adults (up to age 21) with certain types of leukemia or related blood cancers that have come back or not responded to standard therapy. The treatment involves collecting the patient's own immune cells (or a donor's), modifying them to recognize and attack cancer cells, and giving them back after a short course of chemotherapy. The main goal is to find the safest dose and to see if the cells can reduce or eliminate the cancer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia B-cell acute lymphoblastic leukemia Blastic Plasmacytoid Dendritic Cell Neoplasm CD4+/CD56+ hematodermic neoplasm mixed phenotype acute leukemia myelodysplastic syndrome precursor B-cell acute lymphoblastic leukemia precursor T-cell acute lymphoblastic leukemia Precursor T-Cell Lymphoblastic Leukemia-Lymphoma T-cell acute lymphoblastic leukemia therapy related acute myeloid leukemia and myelodysplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AML/MDS B-ALL BPDCN T-ALL

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • St Jude Children's Research Hospital

    RECRUITING

    Memphis, Tennessee, 38105, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • St. Jude Children's Research Hospital

    RECRUITING

    Memphis, Tennessee, 38105, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact