GLIOBLASTOMA

This study is for people with glioblastoma, an aggressive brain tumor. It tests several new treatments at once to see which works best. The goal is to help people live longer and control the disease. About 2,250 participants will join this worldwide effort.

This program provides access to an experimental drug called AVM0703 for patients with various solid tumors and blood cancers, including glioblastoma, breast cancer, and lymphoma. It is available to US patients whose doctors request it. Side effects are mostly mild, such as itchin…

This study tests a combination of drugs (nogapendekin alfa inbakicept, bevacizumab, and immune cells called PD-L1 t-haNK) with or without tumor treatment fields (a device that uses electric fields to disrupt cancer growth) in people whose glioblastoma has come back or worsened. T…

This early-phase study tests a new drug called RSC-1255, alone or with hydroxychloroquine, in adults with advanced solid tumors (like lung, colon, or pancreatic cancer) who have run out of standard treatments. The goal is to find a safe dose and see if the drug can control the di…

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This study tests whether combining three drugs (trimipramine, atezolizumab, and bevacizumab) can help people with recurrent glioblastoma, a fast-growing brain cancer that has returned after standard treatment. About 59 participants will receive the drug combination for up to 2 ye…

This study tests whether adding silibinin (a milk thistle extract) to standard chemoradiation and maintenance chemotherapy can slow the growth of a type of aggressive brain cancer called glioblastoma. About 110 newly diagnosed patients whose tumors have a specific marker (STAT3 p…

This study tests whether proton beam radiation causes fewer side effects than standard photon radiation in people with glioblastoma, a fast-growing brain tumor. About 326 adults will be randomly assigned to one of the two radiation types. The main goal is to see if proton therapy…

This study is testing a small probe called a microdialysis catheter that is placed in the brain during surgery for tumors like glioblastoma or metastatic cancer. The probe collects fluid samples to measure chemicals (biomarkers) in and around the tumor. The goal is to see if this…

This study follows 200 adults with glioblastoma, a severe brain cancer, to understand how genetics, immune system, and personal history affect survival and quality of life. Participants fill out online surveys and may provide a blood sample from home. The goal is to gather inform…

This early-phase study tests if recording electrical activity in and around high-grade glioma tumors during surgery is safe and feasible. Researchers will take small biopsies from recording sites and track tumor progression on follow-up MRI. Ten adults with suspected or recurrent…

This study looks at the genetic makeup of brain tumors in children, teens, and young adults newly diagnosed with high-grade glioma. Researchers will use this information to see if patients qualify for future treatment studies that target their specific tumor type. No treatment is…

This study tests whether testing a patient's own tumor cells in the lab can help doctors choose the most effective drugs for each person with glioblastoma, a fast-growing brain cancer. About 240 newly diagnosed adults will either receive standard treatment or have their tumor cel…

This study is testing whether an artificial intelligence (AI) tool can help connect cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers and use the AI to suggest trials based on their tumor's genetic markers. The goal i…