GLIOBLASTOMA

This study tested two types of brain radiation for people with glioblastoma, an aggressive brain cancer. All participants also received chemotherapy. The goal was to see if a newer, MRI-guided radiation method could help patients live longer than standard radiation. The trial was…

This study tested a new approach for glioblastoma, an aggressive brain cancer. Doctors injected a light-sensitive drug into the tumor and then activated it with a special laser. The goal was to see if it was safe and could help control the cancer. The trial was stopped early afte…

This early-stage study tested a drug called RMC-5552 in 7 adults whose glioblastoma (a type of brain cancer) had returned after standard treatment. The drug works by blocking a protein that helps cancer cells grow. The main goals were to find a safe dose and see if the drug could…

This early-phase trial tested the drug navtemadlin (AMG 232) in 32 adults with glioblastoma, an aggressive brain cancer. The study aimed to find the safest dose and see how much drug reaches the tumor. It was stopped early, but the goal was to control tumor growth, not cure the d…

This study looked at giving chemotherapy and radiation before surgery for a type of brain cancer called glioblastoma. The goal was to see if this approach could help control the tumor better. Only 2 people took part before the study was stopped early. Participants had to be healt…

This early-phase study tested an experimental drug called TAS2940 in 29 people with advanced solid tumors (like lung, breast, or brain cancer) that had specific genetic changes (EGFR or HER2). The goal was to find a safe dose and see if the drug could shrink tumors. The trial was…

This study tested a new drug called zotiraciclib (TG02) combined with temozolomide (TMZ) in adults with recurrent brain tumors (anaplastic astrocytoma or glioblastoma). The goal was to find safe doses and see if the combo works better than TMZ alone. The study was stopped early, …

This study tested a drug called pemigatinib in people whose brain tumors (glioblastoma or other gliomas) had come back after prior treatment and had specific changes in FGFR1-3 genes. Participants took the drug daily for two weeks, then a week off, as long as they benefited. The …

This study tested a new drug called VAL-083 for people with glioblastoma, an aggressive brain cancer, that had returned after standard treatments like temozolomide and bevacizumab. The goal was to see if VAL-083 could help patients live longer compared to other chemotherapy optio…

This study tested whether a special MRI using ferumoxytol (an iron-based contrast agent) can accurately tell the difference between true tumor growth and treatment-related inflammation (pseudoprogression) in people with glioblastoma. About 52 patients were planned to receive stan…

This study aimed to see if a high-CBD hemp product could reduce anxiety and improve quality of life in people newly diagnosed with glioblastoma, a serious brain tumor. The trial planned to compare the CBD product to a placebo over 8 weeks, but it was stopped early after only 2 pe…

This study tested a drug called solriamfetol to see if it could safely help people with brain tumors (gliomas) feel more awake, think clearer, and have a better quality of life. Only 2 people enrolled before the study was stopped early. The main goal was to check for serious side…

This early-phase study tested whether ketoconazole, a drug used for fungal infections, can enter glioblastoma brain tumors in high enough amounts to stop cancer cells from dividing. Only one adult with a high-grade glioma was enrolled before the study was terminated. The goal was…

This early-stage study tested whether posaconazole, a drug normally used for fungal infections, can reach high enough levels in brain tumors to stop cancer cells from dividing. Seven adults with glioblastoma took the drug before surgery to have their tumor removed. The goal was t…

This study looked at a molecule called microRNA-10b in brain tumor samples from 94 adults with gliomas. The goal was to see if higher levels of this molecule could help predict how long patients live or how their tumor behaves. Researchers also tested whether blocking this molecu…

This early-phase trial aimed to measure how much of the drug infigratinib reaches brain tumor tissue in people with recurrent high-grade glioma (a type of brain cancer). Only 7 participants were enrolled before the study was terminated. The main goal was to check drug levels in t…

This early-phase trial tested a single dose of the drug temsirolimus given directly into the brain's arteries before surgery to remove recurrent high-grade gliomas (aggressive brain tumors). Only 5 participants were enrolled, and the main goal was to measure how much drug reaches…