GLIOBLASTOMA

This early-stage study tested an experimental mRNA vaccine called CVGBM in 37 people with a severe brain cancer (glioblastoma or a similar tumor). Participants received the vaccine after surgery and radiation. The main goal was to check safety and find the right dose. The vaccine…

This study tested whether adding an immune cell therapy called Immuncell-LC to standard chemotherapy (temozolomide) helps people with newly diagnosed glioblastoma, an aggressive brain cancer. 180 adults in Korea participated. The goal was to see if the combination slowed cancer g…

This small pilot study tested a new approach for people with recurrent glioblastoma, an aggressive brain cancer that has come back after standard treatments. Six adults received a combination of focused ultrasound (NaviFUS) and the standard drug bevacizumab. The goal was to see i…

This study tested a new surgical technique in 12 people with a fast-growing brain cancer called glioblastoma. Doctors placed a piece of the patient's own tissue into the area where the tumor was removed to bypass the brain's protective barrier. The goal was to see if the procedur…

This study tested whether adding a metabolic therapy program (fasting and a ketogenic diet) to standard treatment (chemoradiation and chemotherapy) is safe and feasible for people with glioblastoma, an aggressive brain cancer. The approach aims to starve cancer cells by lowering …

This early-phase trial tested the safety of adding two drugs, pembrolizumab and vorinostat, to standard chemotherapy and radiation for people newly diagnosed with glioblastoma, an aggressive brain cancer. The study enrolled 21 participants to find the highest safe dose of vorinos…

This early-phase study tested two drugs, ASP8374 and cemiplimab, in 14 people with recurrent glioblastoma, a type of brain cancer. The goal was to find a safe dose and see if giving the drugs before surgery could increase immune cells in the tumor. While the approach aims to cont…

This study tested whether adding whole brain radiation and a drug called plerixafor to the usual chemotherapy and radiation could help people with a fast-growing brain tumor called glioblastoma. 21 patients took part. The goal was to see if the combination could delay tumor growt…

This early-phase study tested whether adding a 16-week ketogenic diet to standard radiation and chemotherapy is safe and doable for people with newly diagnosed glioblastoma, an aggressive brain cancer. Twenty-one adults followed personalized meal plans designed to keep their bodi…

This early-phase trial tested whether adding a mix of THC and CBD (cannabis compounds) to standard chemotherapy and radiation is safe for people with newly diagnosed glioblastoma, an aggressive brain cancer. Thirty-three patients received increasing doses of the cannabis combinat…

This study tested a combination of two drugs (retifanlimab and epacadostat) plus radiation and another drug (bevacizumab) in 51 people with recurrent glioblastoma, a fast-growing brain tumor. The goal was to see if this mix could boost the immune system to fight the tumor and imp…

This study tested whether a device called ExAblate can safely and repeatedly open the blood-brain barrier in 20 patients with high-grade glioma (a serious brain cancer) who were already receiving standard chemotherapy. The goal was to allow more chemotherapy to reach the tumor. T…

This study tested the drug pamiparib, alone or with radiation, in 50 people with glioblastoma (a fast-growing brain cancer). It included both newly diagnosed and recurrent cases. The goal was to see how well the drug reaches the tumor and whether it helps control the disease. Thi…

This early-phase study tested a combination of three treatments—tumor treating fields (a device that uses electric fields to disrupt cancer growth), focused radiation, and chemotherapy—in 12 people with newly diagnosed glioblastoma, an aggressive brain cancer. The main goal was t…

This study tested whether adding the drug azeliragon to standard radiation and chemotherapy (temozolomide) is safe and shows early signs of working in people with newly diagnosed glioblastoma, a fast-growing brain cancer. 33 participants received the combination. The main goals w…

This study tested a new surgical technique that makes glioblastoma tumor cells glow under a special light, helping surgeons remove them more completely. 170 adults with newly diagnosed glioblastoma were randomly assigned to receive either this fluorescence-guided surgery or the s…

This study tested a personalized immunotherapy for people with newly diagnosed glioblastoma, an aggressive brain cancer. Patients received injections of their own immune cells (dendritic cells) trained to attack their tumor. The goal was to see if this treatment is safe and could…

This study tested a new way to guide brain surgery for glioblastoma, a fast-growing and hard-to-treat brain cancer. Doctors used artificial intelligence (AI) to create maps showing where the tumor is likely to come back, then removed extra tissue beyond the visible tumor. The goa…

This study tested a special light therapy given during surgery for glioblastoma, an aggressive brain cancer. Fourteen patients received the treatment, which aims to kill leftover cancer cells after the main tumor is removed. The goal was to find the highest safe light dose to use…

This early-phase study tested the safety and best dose of an experimental drug called ruxolitinib when added to standard brain cancer treatment (radiation and temozolomide) for people with newly diagnosed high-grade gliomas or glioblastoma. The study included 60 participants with…

This study tested whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma, an aggressive brain cancer. About 60 participants received the combination to see if it is safe and improves survival. Th…

This study tested a combination of two drugs, lenvatinib and pembrolizumab, in 611 people with advanced cancers that had stopped responding to standard treatments. The cancers included triple-negative breast, ovarian, gastric, colorectal, glioblastoma, biliary tract, and pancreat…

This study tested a drug called VAL-083 combined with standard radiation in 29 adults with a newly diagnosed aggressive brain cancer (glioblastoma) that has a specific genetic marker (unmethylated MGMT). The goal was to find a safe dose and see if the treatment shrinks tumors. Th…

This study tested a new drug (LY2157299) alone or combined with standard chemotherapy (lomustine) in 158 adults with recurrent glioblastoma, an aggressive brain cancer. The goal was to see if the new drug could help patients live longer or slow tumor growth compared to chemothera…

This early study tested whether a device using focused ultrasound can safely open the blood-brain barrier in 3 patients with high-grade glioma (a type of brain cancer) who were receiving standard chemotherapy. The goal was to let more chemo reach the tumor. The study focused on s…

This early-phase study tested a drug called TG02 in 71 patients with aggressive brain tumors (anaplastic astrocytoma or glioblastoma). Some patients were newly diagnosed and older, while others had tumors that came back. The goal was to find the safest dose of TG02 when given wit…

This pilot study tested whether a light-activated drug (5-ALA) could be safely used during brain surgery to treat glioblastoma, an aggressive brain cancer. Ten adult patients received this experimental therapy in addition to standard surgery and chemoradiation. The main goal was …

This study tested a new treatment for glioblastoma, a fast-growing brain cancer that had come back after initial therapy. The treatment combined a precise, high-dose radiation technique with an immunotherapy drug called durvalumab, which helps the immune system attack cancer cell…

This early-phase study tested a combination of two drugs (low-dose capecitabine and bevacizumab) in 12 people whose glioblastoma brain tumor had come back or continued growing despite prior treatment. The goal was to see if the drugs could reduce certain immune cells (MDSCs) that…

This study tested a type of talk therapy called cognitive behavioral therapy for insomnia (CBT-I) in 70 adults with brain tumors who had trouble sleeping. The goal was to see if the therapy was practical and helpful for this group. Researchers measured how many people signed up, …

This study tested whether the blood pressure medication Ramipril could help prevent memory loss in 75 people with glioblastoma who were receiving radiation and chemotherapy. Participants took Ramipril during treatment and for four months after. Researchers measured memory and thi…

This study looked at how much lidocaine (a numbing medicine) gets into the tumor and blood of 12 adults during surgery for glioblastoma, a type of brain cancer. The goal was to gather information that could help design better treatments in the future. No new treatment was tested.

This study looked at leftover tumor tissue and blood samples from 141 adults with glioblastoma or other solid tumors who were having surgery. The goal was to measure cell counts and viability to help scientists design better treatments for brain cancer and other solid tumors in t…

This study tested a new way for nurses to support relatives of people with serious brain injuries or brain tumors. The goal was to understand what caregivers need and help them feel more involved. 35 relatives took part across seven hospital units in Denmark. The study focused on…

This study looked at how people with brain tumors or breast cancer perceive their own memory problems, especially remembering to do future tasks. Researchers compared 426 participants, including healthy individuals, to understand the link between memory complaints, depression, an…

This study looked at whether whole genome sequencing (reading all of a tumor's DNA) could help find extra treatment options for people with recurrent glioblastoma, a serious brain cancer. 164 patients who needed a second surgery had their tumor DNA analyzed. The goal was to see i…

This study looked at whether an expensive PET scan called 18F-FDOPA helps doctors choose the right treatment for people with glioblastoma, a serious brain cancer. About 110 patients whose cases were discussed by a team of brain tumor experts were included. The main goal was to se…

This study looked at brain tissue from 20 glioblastoma patients who had received tumor treatment fields (TTFields) therapy. Researchers examined the tissue after death to count active and inactive cancer cells. The goal was to understand how TTFields work at the cellular level.

This study looked back at medical records of 41 patients who had surgery for aggressive brain tumors (high-grade gliomas). Some surgeries used fluorescent dyes that make tumor tissue glow, helping surgeons tell it apart from healthy brain. The goal was to see if using these dyes …

This completed Phase 2 trial studied 47 adults with newly diagnosed glioblastoma or gliosarcoma. Researchers gave patients a combination of immunotherapy drugs (ipilimumab and nivolumab) plus standard chemotherapy (temozolomide) after surgery and initial radiation. The goal was t…

This study looked at whether a combination of two drugs (LY3214996 and abemaciclib) can reach brain tumors in people with recurrent glioblastoma, a type of aggressive brain cancer. About 42 participants took the drugs before surgery to remove their tumor, and researchers measured…

This study looked at 244 people with a newly diagnosed brain cancer called glioblastoma. Researchers wanted to see if changes in platelet levels during early treatment could predict who might develop dangerously low platelets later. The goal was to create a simple monitoring plan…

This study looked at whether special brain scans (PET and CT perfusion) can predict how well the drug bevacizumab works in people with a returning brain tumor called glioblastoma. Fourteen patients were scanned before treatment to see if the images could tell who would respond to…

This study looked at whether video doctor visits work as well as in-person visits for people with brain tumors (gliomas) who are taking chemotherapy pills. Thirty patients alternated between telehealth and in-person checkups, and researchers measured their satisfaction and how mu…

This small pilot study tested whether a type of PET/CT scan (FDG PET/CT) can detect very early changes in glioblastoma (a serious brain cancer) after starting chemotherapy. Seven patients were scanned shortly after beginning therapy to see if changes in tumor sugar use could pred…

This study tested a special PET scan to measure oxygen levels in glioblastoma brain tumors. Low oxygen (hypoxia) can make tumors resistant to treatment. The goal was to find the best way to use this scan to guide therapy. 14 adults with newly diagnosed glioblastoma took part.

This study looked at whether a special MRI technique can identify the most aggressive parts of a glioblastoma brain tumor. Researchers took tissue samples from different areas of the tumor during surgery and tested them for cancer stem cells. The goal was to see if MRI markers ma…